M0567
Microsomes from Liver, Pooled
from human male
Sinonimo/i:
lab equipment accessory
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Codice UNSPSC:
12352204
NACRES:
NA.54
Prodotti consigliati
Origine biologica
human male
Livello qualitativo
Stato
liquid
Confezionamento
vial of ~10 mg
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Applicazioni
Microsomes from Liver, Pooled has been used:
- in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
- as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
- to study the metabolization of enantiomeric peptide D3
Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.
Azioni biochim/fisiol
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.
Source of drug metabolizing enzymes, including cytochrome P-450.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
The enzymatic composition of rat liver microsomes during liver regeneration.
von der DECKEN et al.
Experimental cell research, 19, 591-604 (1960-04-01)
The Carbon Monoxide-binding pigment of liver microsomes II. Solubilization, purification and properties.
Omura, T. and Sato, R.
Journal of Biochemistry, 239, 2379-2385 (1964)
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
T OMURA et al.
The Journal of biological chemistry, 239, 2370-2378 (1964-07-01)
Mohamed W Attwa et al.
Drug design, development and therapy, 14, 4439-4449 (2020-10-31)
Tandutinib (MLN518 or CT 53518) (TND) is a novel, oral, small-molecule inhibitor of type III receptor tyrosine kinases utilized for the treatment of acute myeloid leukemia (AML). In silico prediction of hepatic drug metabolism for TND was determined using the
Ali S Abdelhameed et al.
Royal Society open science, 6(6), 190434-190434 (2019-07-18)
Spebrutinib (SBT) is a Bruton's tyrosine kinase inhibitor. SBT is currently in phase II and phase I clinical trials for the management of rheumatoid arthritis and chronic lymphocytic leukaemia, respectively. We developed and validated a liquid chromatography tandem mass spectrometry
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.