Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

M0398

Sigma-Aldrich

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone

elastase inhibitor, powder, ≥98% (TLC)

Sinonimo/i:

N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethylketone

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C22H35ClN4O7
Numero CAS:
65144-34-5
Peso molecolare:
502.99
Beilstein:
6167019
Numero MDL:
MFCD00077136
Codice UNSPSC:
12352202
ID PubChem:
24896552
NACRES:
NA.77

product name

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, elastase inhibitor

Saggio

≥98% (TLC)

Forma fisica

powder

Punto di fusione

159 °C

Solubilità

methanol: 50 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)CCl

InChI

1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1
PJGDFLJMBAYGGC-XLPNERPQSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.

Applicazioni

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone has been used as an elastase specific inhibitor.

Azioni biochim/fisiol

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).
Irreversible inhibitor of human leukocyte and neutrophil elastase.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 7

1 of 7

N-succinil-Ala-Ala-Pro-Phe-p-nitroanilide

Sigma-Aldrich

S7388

N-succinil-Ala-Ala-Pro-Phe-p-nitroanilide

Elastase from porcine pancreas Type IV, Protein 50-90 %, lyophilized powder, ≥4.0 units/mg protein (biuret)

Sigma-Aldrich

E0258

Elastase from porcine pancreas

Elastase from human leukocytes lyophilized powder, ≥50 units/mg protein (Bradford)

Sigma-Aldrich

E8140

Elastase from human leukocytes

Potassium cyanide BioUltra, ≥98.0% (AT)

Sigma-Aldrich

60178

Potassium cyanide

Amfotericina B 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture

Sigma-Aldrich

A2942

Amfotericina B

1,10-Phenanthroline ≥99%

Sigma-Aldrich

131377

1,10-Phenanthroline

Dimetil solfossido Hybri-Max™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

D2650

Dimetil solfossido

V S Carl et al.
Immunopharmacology, 33(1-3), 325-329 (1996-06-01)
Bradykinin (BK) is a potent inflammatory mediator, which can release other inflammatory mediators by interacting with bradykinin B1 and B2 receptors. The role of kinins in regulating human PMN elastase release was studied. BK induced elastase release 5-fold over basal
Prevention of elastase-induced experimental emphysema by oral administration of a synthetic elastase inhibitor.
A Janoff et al.
The American review of respiratory disease, 121(6), 1025-1029 (1980-06-01)
Proteolytic cleavage of annexin 1 by human leukocyte elastase
Rescher U, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1763(11), 1320-1324 (2006)
L A Smedly et al.
The Journal of clinical investigation, 77(4), 1233-1243 (1986-04-01)
The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines neutrophil-mediated injury to human microvascular endothelial cells in vitro. We found that neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine (FMLP), the complement fragment C5a, or
Takeshi Kawamura et al.
Microbiology and immunology, 46(3), 225-230 (2002-05-15)
Carboxypeptidase R (EC 3.4.17.20; CPR) is an unstable basic carboxypeptidase found in fresh serum in addition to carboxypeptidase N (CPN) which is a stable enzyme. CPR in fresh serum is generated from its zymogen (proCPR) during coagulation by trypsin-like enzymes
Visualizza tutti i documenti correlati

Articoli

Elastase

Enzyme Explorer Product Application Index for Elastase. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.