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L8543

Sigma-Aldrich

DL-Lanthionine

≥98% (TLC)

Sinonimo/i:

DL-3,3′-thiodi-Alanine, S-(2-amino-2-carboxyethyl)-DL-Cysteine

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About This Item

Formula empirica (notazione di Hill):
C6H12N2O4S
Numero CAS:
Peso molecolare:
208.24
Numero CE:
Codice UNSPSC:
12352209
NACRES:
NA.26

product name

DL-Lanthionine, ≥98% (TLC)

Saggio

≥98% (TLC)

Forma fisica

powder

Colore

white

Solubilità

1 M HCl: soluble

applicazioni

detection

InChI

1S/C6H12N2O4S/c7-3(5(9)10)1-13-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)
DWPCPZJAHOETAG-UHFFFAOYSA-N

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Categorie correlate

Applicazioni


  • Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase.: This research highlights innovative methods for synthesizing peptide-based antibiotics like lactocin S, utilizing dl-lanthionine to form crucial thioether crosslinks that enhance the activity and stability of these peptides (Ross et al., 2010).

  • Cystathionine gamma-lyase of Streptomyces phaeochromogenes.: This research documents the isolation and characterization of an enzyme that processes cystathionine, which involves dl-lanthionine as a structural analog, revealing its role in bacterial physiology and potential applications in biotechnology (Nagasawa et al., 1984).

  • The availability of dl-lanthionine for the promotion of growth in young rats when added to a cystine- and methionine-deficient diet.: This historical study explores the nutritional value of dl-lanthionine, investigating its ability to substitute for essential amino acids in growth diets, which helps in understanding its potential use in nutritional supplements (Jones et al., 1948).

Azioni biochim/fisiol

Lanthionine is a non-typical amino acid and a monosulfide analog of cystine. Lanthionines are constituents of a group of peptide antibiotics called lantiobiotics, which include nisin and subtilin.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Glutathione Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

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Ayşe Ökesli et al.
Journal of the American Chemical Society, 133(34), 13753-13760 (2011-07-21)
Lantibiotics are ribosomally synthesized and post-translationally modified antimicrobial peptides that are characterized by the thioether cross-linked amino acids lanthionine (Lan) and methyllanthionine (MeLan). Cinnamycin is a 19 amino acid lantibiotic that contains one Lan and two MeLan. Cinnamycin also contains
Antonino Mavaro et al.
The Journal of biological chemistry, 286(35), 30552-30560 (2011-07-16)
Nisin is a posttranslationally modified antimicrobial peptide containing the cyclic thioether amino acids lanthionine and methyllanthionine. Although much is known about its antimicrobial activity and mode of action, knowledge about the nisin modification process is still rather limited. The dehydratase
Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes.
Bruzzone S, Basile G, Mannino E, et al.
Journal of Cellular Physiology, 227(6), 2502-2510 (2011)
Wolfgang M Müller et al.
Biochemistry, 50(39), 8362-8373 (2011-09-13)
Lantibiotics are peptide antibiotics, realizing their unique secondary structure by posttranslational modifications, the most important one being the formation of the characteristic amino acid lanthionine. Like other ribosomal peptide antibiotics, they are synthesized with an N-terminal leader peptide important for
Jun-ichi Nagao et al.
Current pharmaceutical biotechnology, 12(8), 1221-1230 (2011-04-08)
Lantibiotics are ribosomally synthesized, post-translationally modified, peptide antibiotics containing unusual amino acids such as dehydrated amino acids and lanthionine. These unusual amino acids impose conformational constraints on the peptide and contribute to the biological activity and high physicochemical stability of

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