L7795

Levocetirizine dihydrochloride

≥98% (HPLC)

• Sinonimo/i: Levocetirizine dihydrochloride, (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
• Formula empirica (notazione di Hill): C₂₁H₂₅ClN₂O₃·2HCl
• Numero CAS: 130018-87-0
• Peso molecolare: 461.81
• Numero MDL: MFCD07366507
• Codice UNSPSC: 12352200
• ID PubChem: 329817657
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Solubilità: H₂O: ≥23 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1; PGLIUCLTXOYQMV-GHVWMZMZSA-N
• Informazioni sul gene: human ... HRH1(3269)

Descrizione

Descrizione generale

Levocetirizine dihydrochloride is the R-enantiomer of cetirizine and is used for treating seasonal allergic rhinitis and chronic idiopathic urticaria. The liver metabolizes 14% of levocetirizine and rest is excreted in urine. The response of levocetirizine to histamine is comparatively higher to cetirizine.

Applicazioni

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.

Azioni biochim/fisiol

Levocetirizine dihydrochloride is a nonsedating type histamine H1-receptor antagonist; active isomer of cetirizine

Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

Caratteristiche e vantaggi

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H400
• Consigli di prudenza: P273 - P301 + P312 + P330
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Acute 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable