J4144

Jo-1 human

recombinant, expressed in E. coli, solution

• Numero MDL: MFCD03457272
• Codice UNSPSC: 12352204
• NACRES: NA.83

Proprietà

• Ricombinante: expressed in E. coli
• Livello qualitativo: 200
• Stato: solution
• PM: 55 kDa by SDS-PAGE
• N° accesso UniProt: P12081
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... HARS(3035)

Descrizione

Descrizione generale

Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity.

Azioni biochim/fisiol

The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyositis patients.

Used in the immunoassay for antibodies to Jo-1.

Stato fisico

Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable