H5915
2,3-Bis(4-hydroxyphenyl)propionitrile
≥98% (HPLC)
Sinonimo/i:
DPN, Diarylpropionitrile, SC-4473
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About This Item
Formula empirica (notazione di Hill):
C15H13NO2
Numero CAS:
Peso molecolare:
239.27
Numero MDL:
Codice UNSPSC:
51111800
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Sterilità
non-sterile
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Condizioni di stoccaggio
desiccated
Colore
white to beige
Solubilità
DMSO: 10 mg/mL, clear
Condizioni di spedizione
ambient
Temperatura di conservazione
−20°C
Stringa SMILE
Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
InChI
1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
GHZHWDWADLAOIQ-UHFFFAOYSA-N
Azioni biochim/fisiol
2,3-Bis(4-hydroxyphenyl)-propionitrile (Diarylprepionitrile, DPN) is an ERβ-selective agonist; IC50 = 15nM. DPN protects WT and ARKO mice and significantly decreases IL-1β following LPS treatment in young adult-derived microglia. PPT (Cat. No.H6036, ERa agonist) enhances cell proliferation, while DPN inhibits it. PPT increases Bcl-2 expression, while DPN decreases it. DPN also elevates Bax expression. DPN induces a dose-dependent increase on vitellogenin synthesis. PPT and DPN are effective in dynamically, but differentially regulating intracellular calcium signaling in hippocampal neurons. DPN is more efficacious than PPT in potentiating a physiological concentration of glutamate-induced intracellular Ca2+ rise in these neurons. DPN prevents the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.
2,3-Bis(4-hydroxyphenyl)-propionitrile is an ERβ-selective agonist; IC50 = 15nM.
Caratteristiche e vantaggi
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Aquatic Acute 1 - Eye Irrit. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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