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Key Documents

H4890

Sigma-Aldrich

Anti-Human Hemoglobin antibody produced in rabbit

whole antiserum

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.43

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

whole antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

contiene

15 mM sodium azide

Reattività contro le specie

human

tecniche

indirect ELISA: 1:8,000

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... HBB(3043)

Descrizione generale

HBB (hemoglobin subunit β) codes for a β globin that consists of three exons. This gene is located on human chromosome 11p15. HBB is a serum protein that belongs to the histone-like protein family.

Immunogeno

Hemoglobin isolated from normal adult human red blood cells and treated to remove lipoproteins.

Applicazioni

Anti-Human Hemoglobin antibody has been used in pulse chase experiments and western blotting.
Anti-Human Hemoglobin antibody produced in rabbit was used for immunoblotting using crude human cerebellar protein extracts and membrane extracts of human RBC. It was used for immunohistochemistry of human tongue cancer samples.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Azioni biochim/fisiol

HBB (hemoglobin subunit β) participates in oxygen transport from the lung to various peripheral tissues. Mutation in HBB result in Sickle cell disease (SCD). Overexpression of HBB has been observed in patients with periodontal disease.
Hemoglobin (Hb) is oxygen-binding metalloprotein that is present in the red blood cells. The most abundant Hb is HbA tetramer that is made up of two α, two β chains and the nonprotein heme group. The heme group contains iron ion and a porphyrin ring. Mutations in Hb gene result in hemoglobinopathies, the best known being sickle-cell disease and thalassemias.

Nota sulla preparazione

treated to remove lipoproteins

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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I clienti hanno visto anche

Amritha Suresh et al.
Disease markers, 32(1), 51-64 (2012-02-03)
Worldwide, the incidence of oral tongue cancer is on the rise, adding to the existing burden due to prevailing low survival and high recurrence rates. This study uses high-throughput expression profiling to identify candidate markers of resistance/response in patients with
P D Wagner
The European respiratory journal, 31(4), 887-890 (2008-04-02)
The biology of O(2) is extremely complex and defies a comprehensive yet brief summary that showcases its roles across the entire animal and plant kingdom. This necessarily short introduction to the 2006 Taormina Lung Science Conference (Taormina, Italy) on hypoxia
Respiratory function of hemoglobin.
C C Hsia
The New England journal of medicine, 338(4), 239-247 (1998-01-22)
A phylogenetic analysis of Borrelia burgdorferi sensu lato based on sequence information from the hbb gene, coding for a histone-like protein
Valsangiacomo C, et al.
International Journal of Systematic and Evolutionary Microbiology, 47(1), 1-10 (1997)
Sandrine Delbosc et al.
Frontiers in cardiovascular medicine, 4, 43-43 (2017-08-22)
Since red blood cells (RBCs) are the predominant cellular blood component interacting with the arterial wall, we explored the role of RBCs efferocytosis by vascular smooth muscle cells (vSMCs) in the initiation of human atheroma. The comparison of human healthy

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