GE17-5481-01
Capto™ Core 700
Cytiva 17-5481-01, pack of 25 mL
Sinonimo/i:
Capto Core, Capto Core 700
About This Item
Prodotti consigliati
ligand
octylamine
Confezionamento
pack of 25 mL
Produttore/marchio commerciale
Cytiva 17-5481-01
Matrice
highly cross-linked agarose
Dimens. media delle particelle
75 (d₅₀v is the median particle size of the cumulative volume distribution)
cleaning in place
3-13(pH interval where the medium can be subjected to, for cleaning- or sanitization-in-place.)
working range
2-14(pH interval where the medium can be operated without significant change in function.)
Capacità
~13 mg binding capacity (ovalbumin)
Compatibilità
suitable for bioprocess medium
Descrizione generale
Multimodal removal of contaminants
Capto Core 700 is composed of a ligand-activated core and inactive shell. The inactive shell excludes large molecules (cut off ~ Mr 700 000) from entering the core through the pores of the shell. These larger molecules are collected in the column flowthrough while smaller impurities bind to the internalized ligands.
Hydrophobic, positively charged ligands
The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core. The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations. Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent.
Scaling up is simple
HiTrap and HiScreen columns can be connected in series for increased capacity and are convenient to use when developing an efficient and robust separation method.
Applicazioni
- Multimodal contaminate removal
- Virus and exosome purification
- Process development
- Biomolecule purification
Caratteristiche e vantaggi
- Novel core bead technology allows efficient capture of contaminants while target molecules are collected in the flowthrough.
- Significantly improved productivity and higher flow rates compared with standard size exclusion (gel filtration) methods.
- Straightforward optimization due to flowthrough chromatography and robust performance.
- Convenient small-scale purification, process development, and scale-up using prepacked HiTrap and HiScreen columns.
- Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
Stoccaggio e stabilità
Risultati analitici
Note legali
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Codice della classe di stoccaggio
3 - Flammable liquids
Certificati d'analisi (COA)
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Articoli
This page describes the maintenance of media and storage conditions for multimodal chromatography using GE Healthcare products.
Protocolli
Capto Core 700 from GE Healthcare is designed for intermediate purification and polishing of viruses and other large biomolecules in flowthrough mode.
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