G6649

Genistein

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

• Sinonimo/i: 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Formula empirica (notazione di Hill): C₁₅H₁₀O₅
• Numero CAS: 446-72-0
• Peso molecolare: 270.24
• Beilstein: 263823
• Numero CE: 207-174-9
• Numero MDL: MFCD00016952
• Codice UNSPSC: 12352200
• ID PubChem: 24278036
• NACRES: NA.77

Proprietà

• product name: Genistein, synthetic, ≥98% (HPLC), powder
• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: off-white to yellow
• Punto di fusione: 297.0-298.0 °C
• Solubilità: DMSO: soluble; ethanol: soluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H; TZBJGXHYKVUXJN-UHFFFAOYSA-N
• Informazioni sul gene: human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100) ; mouse ... Esr1(13982) , Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

Descrizione

Descrizione generale

Genistein is an isoflavonoid present among Leguminosae family of plants. It is structurally similar to estrogen (estradiol-17β).

Applicazioni

Genistein has been used:

• as a test compound to access its estrogeniic acivity
• as an oestrogenic ligand to carry out identical reporter gene activation assays and also used to examine the binding of genistein to hERβ
• as an endocytosis inhibitor to test the possible effect of endocytosed advanced glycation end - bovine serum albumin (AGE-BSA) on lysosomes

Azioni biochim/fisiol

Genistein is essential for plant-microbe interaction. It acts as a natural chemoprotectant and helps in preventing tumor progression and heart disorders. Genistein functionally shares estrogen′s action. It is useful in evaluating nutraceuticals and functional foods. Genistein exhibits antimicrobial action and can serve as a phytoalexin and phytoanticipin.

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Chloride Channels and Met pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

Genistein is soluble in DMSO and ethanol. It is also soluble in chlorform:methanol (1:1 (v:v), 10 mg/ml).

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type N95 (US)