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G2128

Sigma-Aldrich

L-Glutamic acid hydrochloride

Sinonimo/i:

(S)-2-Aminoglutaric acid, (S)-2-Aminopentanedioic acid ammonium salt, Glu HCl

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About This Item

Formula empirica (notazione di Hill):
C5H9NO4 · HCl
Numero CAS:
138-15-8
Peso molecolare:
183.59
Beilstein:
3565569
Numero CE:
205-315-9
Numero MDL:
MFCD00012619
Codice UNSPSC:
12352106
ID PubChem:
24277982
NACRES:
NA.32

Stringa SMILE

Cl.N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
RPAJSBKBKSSMLJ-DFWYDOINSA-N

Informazioni sul gene

human ... GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901)

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Descrizione generale

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

Applicazioni

L-Glutamic acid hydrochloride has been used as a nutrient additive to study the effect of increased dissolved inorganic nitrogen (DIN) on the uptake of dissolved organic nitrogen (DON) and dissolved organic carbon (DOC), in a nitrogen-limited headwater forest stream.

Azioni biochim/fisiol

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314

Classi di pericolo

Eye Dam. 1 - Skin Corr. 1

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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L-Glutamic acid monopotassium salt monohydrate puriss. p.a., ≥99.0%

Sigma-Aldrich

49601

L-Glutamic acid monopotassium salt monohydrate

L-4-Hydroxyproline methyl ester hydrochloride ≥98.0% (GC)

Sigma-Aldrich

30681

L-4-Hydroxyproline methyl ester hydrochloride

Coupled cycling of dissolved organic nitrogen and carbon in a forest stream.
Brookshire E N J et al
Ecology, 86(9), 2487-2496 (2005)
Martina Curto et al.
The journal of headache and pain, 17, 47-47 (2016-05-01)
Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such as kynureninic acid (KYNA), quinolinic acid (QUINA), and xanthurenic
B K Day et al.
Journal of neurochemistry, 96(6), 1626-1635 (2006-01-31)
L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system. It plays major roles in normal neurophysiology and many brain disorders by binding to membrane-bound Glu receptors. To overcome the spatial and temporal limitations encountered in previous
Wei Lu et al.
Neuron, 78(3), 433-439 (2013-05-15)
The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly
A new beginning for a broken mind: balancing neuregulin 1 reverses synaptic dysfunction.
Oscar Marín et al.
Neuron, 78(4), 577-579 (2013-05-31)
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