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E5750

Sigma-Aldrich

Ergocalciferol

40,000,000 USP units/g

Sinonimo/i:

Calciferol, Ercalciol, Ergosterol irradiated, Irradiated ergosterol, Vitamin D2

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About This Item

Formula empirica (notazione di Hill):
C28H44O
Numero CAS:
50-14-6
Peso molecolare:
396.65
Beilstein:
1916682
Numero CE:
200-014-9
Numero MDL:
MFCD00166988
Codice UNSPSC:
12352205
eCl@ss:
34058017
ID PubChem:
24894344
NACRES:
NA.79

Origine biologica

synthetic (organic)

Livello qualitativo

200

Saggio

≥97%

Forma fisica

powder

Attività specifica

40,000,000 USP units/g

tecniche

HPLC: suitable

Colore

white to off-white

Punto di fusione

114-118 °C (lit.)

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1
MECHNRXZTMCUDQ-RKHKHRCZSA-N

Informazioni sul gene

human ... VDR(7421)

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Categorie correlate

Descrizione generale

Vitamin D2 or ergocalciferol is available through dietary supplements or plant sources. It is a provitamin, which is fat-soluble.

Applicazioni

Ergocalciferol has been used as a component of the diet for rats, to study its bioavailability from ultraviolet-irradiated D2-rich yeast. It has also been used as a standard for identification and quantification of vitamins, as part of a study to determine the nutritional composition of food fishes.

Azioni biochim/fisiol

Ergocalciferol (vitamin D2) and 25-Hydroxycholecalciferol (vitamin D3) are the two forms of vitamin D, which are activated in vivo by hydroxylation. Vitamin D2 and D3 may be used in a wide range of studies to assess their effects on function such as immune function and calcium homeostasis.
Ergocalciferol is used for antirachitic treatment. Vitamin D has an active role in bone mineralization. Severe deficiency of this vitamin has been associated with osteomalacia and rickets.

Confezionamento

Sealed ampule.

Quantità

1 USP unit = 1 I.U.

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Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311,H330,H372

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Supelco

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SAFC

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Supelco

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Sigma-Aldrich

R7882

Retinil acetato

Vitamin D2 solution 100 μg/mL in ethanol, 98% (CP)

Sigma-Aldrich

740306

Vitamin D2 solution

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Supelco

V-024

Vitamin D2 solution

Rock E
Food for the Ageing Population (2009)
Vitamin D: The Biotechnology of Ergosterol
Vandamme EJ
Biotechnology of microbial enzymes (1989)
Poor bioavailability of vitamin D2 from ultraviolet-irradiated D2-rich yeast in rats
Itkonen ST, et al.
Nutrition Research (New York, N.Y.), 59, 36-43 (2018)
Dietary Reference Intakes for Calcium and Vitamin D (2011)
Nutritional composition of food fishes and their importance in providing food and nutritional security
Mohanty BP, et al.
Food Chemistry, 293 (2019)
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Articoli

Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed by 7-dehydrocholesterol, which is found within the plasma membranes of epidermal and dermal skin layers. This reaction yields an unstable derivative of 7-dehydrocholesterol, named precholecalcitrol, which rapidly rearranges to vitamin D3. Vitamin D binding protein (DBP) is a carrier protein responsible for drawing vitamin D3 from the plasma membrane into the dermal capillaries within the extracellular space.

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