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D9571

Sigma-Aldrich

Dolasetron mesylate hydrate

≥98% (HPLC), powder

Sinonimo/i:

Anzemet hydrate, Dolasetron methanesulfonate hydrate

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About This Item

Formula empirica (notazione di Hill):
C19H20N2O3 · CH4O3S · xH2O
Numero CAS:
115956-13-3
Peso molecolare:
420.48 (anhydrous basis)
Codice UNSPSC:
12352200
ID PubChem:
329798907
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to off-white

Solubilità

H2O: >30 mg/mL

Ideatore

Sanofi Aventis

Temperatura di conservazione

2-8°C

Stringa SMILE

O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45

InChI

1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;
QTFFGPOXNNGTGZ-BHSFMSKKSA-N

Azioni biochim/fisiol

Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

Caratteristiche e vantaggi

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Christopher M Peters et al.
Brain research, 1352, 83-93 (2010-07-20)
The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by
Sarah Turner et al.
Journal of clinical anesthesia, 19(8), 622-625 (2007-12-18)
A 52-year-old woman with hypertension and Graves' disease was scheduled for surgical removal of a meningioma. Intraoperative events were significant for hypotension requiring a vasopressin infusion. Prophylactic dolasetron was administered to the patient before emergence. The patient's trachea was easily
Dolasetron and QT interval.
C Page et al.
Emergency medicine journal : EMJ, 25(10), 706-706 (2008-10-10)
Antiemetic agents.
Gail Wilkes
Oncology (Williston Park, N.Y.), 21(8 Suppl), 48-48 (2007-09-12)
[Palonosetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) in Italy: pharmacologic, clinical and economic aspects].
Lorenzo Pradelli et al.
Tumori, 94(2), suppl 26-suppl 32 (2008-06-21)
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