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D7408

Sigma-Aldrich

2′,5′-Dideoxyadenosine

≥95% (HPLC), solid

Sinonimo/i:

2ʹ,5ʹ-dd-Ado, NSC 95943

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About This Item

Formula empirica (notazione di Hill):
C10H13N5O2
Numero CAS:
6698-26-6
Peso molecolare:
235.24
Numero MDL:
MFCD00210904
Codice UNSPSC:
41106305
ID PubChem:
24894132
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥95% (HPLC)

Forma fisica

solid

Colore

white

Solubilità

DMSO: soluble

Temperatura di conservazione

−20°C

Stringa SMILE

C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
FFHPXOJTVQDVMO-DSYKOEDSSA-N

Informazioni sul gene

rat ... Adcy2(81636)

Applicazioni

2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).

Azioni biochim/fisiol

Cell-permeable adenylyl cyclase inhibitor. IC50 = 2.7 μM in detergent-dispersed rat brain preparations.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Ricostituzione

Store at −20 °C after reconstitution.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

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Rula Azzam et al.
AIDS research and human retroviruses, 22(7), 619-629 (2006-07-13)
HIV-1 infection of cells of macrophage lineage impairs a number of effector functions performed by these cells, including phagocytosis of opsonized pathogens. In this study we investigate the effects of HIV-1 on the mechanism of complement (C')-mediated phagocytosis by human
Gastroprotective effect of diligustilide isolated from roots of Ligusticum porteri coulter & rose (Apiaceae) on ethanol-induced lesions in rats
Velazquez-Moyado J, et al.
Journal of Ethnopharmacology, 174, 403-409 (2015)
Yukihisa Matsumoto et al.
PloS one, 8(7), e68538-e68538 (2013-07-31)
Many insects exhibit excellent capability of visual learning, but the molecular and neural mechanisms are poorly understood. This is in contrast to accumulation of information on molecular and neural mechanisms of olfactory learning in insects. In olfactory learning in insects
Fen Hu et al.
Molecular medicine reports, 24(4) (2021-07-31)
Inflammation and oxidative stress have indispensable roles in the development of acute lung injury (ALI). MicroRNA (miRNA/miR)‑351‑5p was initially identified as a myogenesis‑associated miRNA; however, its role in lipopolysaccharide (LPS)‑induced ALI remains unclear. The aim of the present study was
Hyun-Seuk Moon et al.
Journal of cellular physiology, 214(2), 283-294 (2007-07-27)
We previously reported that PEGylated conjugated linoleic acid (PCLA) as a pro-drug treatment of cultures of 3T3-L1 cells containing differentiated adipocytes caused de-differentiation by downregulation of PPARgamma2-induced adipogenesis, and cell apoptosis induced by PCLA was lower than that induced by
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