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D1069

Sigma-Aldrich

Desloratadine

powder, ≥98% (HPLC)

Sinonimo/i:

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®

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About This Item

Formula empirica (notazione di Hill):
C19H19ClN2
Numero CAS:
100643-71-8
Peso molecolare:
310.82
Numero MDL:
MFCD00871949
Codice UNSPSC:
12352200
ID PubChem:
329798668
NACRES:
NA.32

Saggio

≥98% (HPLC)

Forma fisica

powder

Solubilità

DMSO: >10 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1

InChI

1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
JAUOIFJMECXRGI-UHFFFAOYSA-N

Informazioni sul gene

human ... HRH1(3269)

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Applicazioni

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

Azioni biochim/fisiol

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Note legali

Clarinex is a registered trademark of Schering Corp.

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

390.2 °F - Pensky-Martens closed cup

Punto d’infiammabilità (°C)

199 °C - Pensky-Martens closed cup

Certificati d'analisi (COA)

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