C8198
Anti-Calcitonin Gene Related Peptide antibody produced in rabbit
whole antiserum
Sinonimo/i:
CGRP Antibody - Anti-Calcitonin Gene Related Peptide antibody produced in rabbit, Cgrp Antibody, Anti-CGRP
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About This Item
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
whole antiserum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
contiene
15 mM sodium azide
Reattività contro le specie
rat
Confezionamento
antibody small pack of 25 μL
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
rat ... Calca(24241)
Descrizione generale
Calcitonin Gene Related Peptide (CGRP), a cyclic peptide, belongs to a small family of peptides encoded by the calcitonin/CGRP gene complex. The calcitonin/CGRP gene complex consists of at least two genes, encoding for two forms of CGRP: -CGRP (CGRP-I) and -CGRP (CGRP-II). CGRP is synthesized and co-localized with calcitonin in the parafollicular C-cells of the thyroid gland and medullary thyroid carcinoma. It is principally considered a neuropeptide widely distributed in the central and peripheral nervous systems.
Specificità
Anti-Calcitonin Gene Related Peptide reacts with CGRP (rat). Cross-reactivity is observed with CGRP (human) and β-CGRP (human).
Immunogeno
CGRP-KLH
Applicazioni
Anti-Calcitonin Gene Related Peptide antibody produced in rabbit has been used in:
- dot blot immunoassay
- fluorescent labeling
- confocal microscopy
- immunohistofluorescence
- epifluorescence imaging
Anti-Calcitonin Gene Related Peptide antibody produced in rabbit was used for immunohistochemistry of trigeminal ganglia cell cultures at a dilution of 1:200 and for immunocytochemistry of mouse lung slices at a dilution of 1:500.
Azioni biochim/fisiol
CGRP is thought to act as a neurotransmitter or neuromodulator, particularly in the regulation of autonomic (e.g., cardiovascular, respiratory, gastrointestinal, taste, food intake and sleep) and limbic functions. CGRP is probably involved with substance P in mediating neurogenic inflammation and transmission of pain stimuli via the peripheral nervous system.
Calcitonin Gene Related Peptide is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.
Quantità
delipidized
Stato fisico
Supplied as a liquid containing 0.1% sodium azide as a preservative
Stoccaggio e stabilità
For continuous use, store 2-8°C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free"freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I clienti hanno visto anche
Juan M Jimenez-Andrade et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(44), 14649-14656 (2010-11-05)
Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing tissue undergo
Lina Almarestani et al.
Molecular pain, 4, 56-56 (2008-11-19)
Pain is a major symptom associated with chronic inflammation. In previous work from our laboratory, we have shown that in animal models of neuropathic pain there is a sprouting of sympathetic fibers into the upper dermis, a territory normally devoid
Kumiko Ishida et al.
Anesthesiology, 121(5), 1068-1079 (2014-07-06)
The aim of this study was to clarify the roles of calcitonin gene-related peptide (CGRP) in postoperative pain and inflammatory pain. αCGRP knockout mice that the authors have developed and wild-type mice were used. Pain behaviors were assessed after incision
Eric L Moore et al.
British journal of pharmacology, 166(1), 66-78 (2011-08-30)
The clinical effectiveness of antagonizing the calcitonin gene-related peptide (CGRP) receptor for relief of migraine pain has been clearly demonstrated, but the road to the development of these small molecule antagonists has been daunting. The key hurdle that needed to
Shin-E Lin et al.
Physiological reports, 3(12) (2015-12-25)
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