C8195
Complement C4 from human serum
≥300,000 C4H50 units/mg protein
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About This Item
Origine biologica
human serum
Livello qualitativo
Forma fisica
solution
Attività specifica
≥300,000 C4H50 units/mg protein
tecniche
activity assay: suitable
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... C4A(720)
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Descrizione generale
Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.
Applicazioni
Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.
Azioni biochim/fisiol
Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.
There are strong indications that complement C4 deficiency is correlated with induction of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Stato fisico
Supplied as a solution in PBS, pH 7.2
Altre note
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Esclusione di responsabilità
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)
Grassmann F, et al.
Journal of Neuroinflammation, 13(1), 81-81 (2016)
Structural basis for activation of the complement system by component C4 cleavage
Kidmose RT, et al.
Proceedings of the National Academy of Sciences of the USA, 109, 15425-15430 (2012)
Structural basis for the function of complement component C4 within the classical and lectin pathways of complement
Mortensen S, et al
Journal of Immunology (2015)
Schizophrenia risk from complex variation of complement component 4
Sekar A, et al.
Nature, 530(7589), 177-177 (2016)
Three novel single-nucleotide polymorphisms of complement component 4 gene (C4A) in Chinese Holstein cattle and their associations with milk performance traits and CH50.
Yang Y., et al.
Veterinary Immunology and Immunopathology (2011)
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