Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

C8788

Sigma-Aldrich

Complement C3 deficient serum human

substrate serum for C3 activity

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

human

Livello qualitativo

Forma fisica

solution

impiego

substrate serum for C3 activity

tecniche

activity assay: suitable

Impurezze

infectious agent, tested

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... C3(718)

Descrizione generale

Complement C3 deficient serum is a normal human serum in which C3 protein is removed by affinity chromatography. Depleted serum helps in the complement cascade up to the preferred convertase level. It eases the formation of enzyme complex from purified components.

Applicazioni

Complement C3 deficient serum human has been used:
  • as a component of the culture medium to study the influence of the inhibition of complement activation on complement receptors (CR3 and C3aR) expression in CD3+CD56+NKT-like cells
  • as a negative control to evaluate the downstream complement activation post-mannan-binding lectin (MBL) pathway activation
  • to study the opsonization of foreign particles by complement system

Stato fisico

Supplied as a solution in phosphate buffered saline, pH 7.4

Risultati analitici

C3 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Marcin Okroj et al.
PloS one, 7(10), e47245-e47245 (2012-10-17)
C3 and C5 convertases are central stages of the complement cascade since they converge the different initiation pathways, augment complement activation by an amplification loop and lead to a common terminal pathway resulting in the formation of the membrane attack
Shin Yong Park et al.
Journal of immunology (Baltimore, Md. : 1950), 181(9), 6328-6336 (2008-10-23)
Enterococcus faecalis (Ef) accounts for most cases of enterococcal bacteremia, which is one of the principal causes of nosocomial bloodstream infections (BSI). Among several virulence factors associated with the pathogenesis of Ef, an extracellular gelatinase (GelE) has been known to

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.