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Key Documents

C7602

Sigma-Aldrich

L-Cistina

98.5-101.0%, suitable for cell culture, BioXtra, non-animal source

Sinonimo/i:

Acido (R,R)-3,3′-ditio-bis(2-ammino-propionico)

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About This Item

Formula condensata:
[-SCH2CH(NH2)CO2H]2
Numero CAS:
Peso molecolare:
240.30
Beilstein:
1728094
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
NACRES:
NA.26

product name

L-Cistina, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%

Origine biologica

non-animal source

Livello qualitativo

agenzia

meets EP testing specifications

Nome Commerciale

BioXtra

Saggio

98.5-101.0%

Forma fisica

powder

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, tested

Colore

white to off-white

Punto di fusione

>240 °C (dec.) (lit.)

Solubilità

1 M HCl: 100 mg/mL

applicazioni

peptide synthesis

Stringa SMILE

N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
LEVWYRKDKASIDU-IMJSIDKUSA-N

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Applicazioni

L-Cystine has been used as a supplement in astroglial-conditioned media to culture cerebral astroglia. It has been used in several techniques, such as HPLC-FD, UHPLC-UV, UHPLC-MS, and triple quadrupole tandem mass spectrometry (UHPLC-MS/MS), to differentiate BMAA (β-N-methylamino-L-alanine), the cyanobacterial neurotoxin, from other diamino acids.
L-Cystine has been used as a supplement in oocyte culture media to improve oocyte maturation and parthenogenesis of embryonic development.

Azioni biochim/fisiol

Cystinuria is characterized with renal transport and excretion of L-Cystine. Cysteine is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Cysteine is a source of disulfide linkage in protein and is associated with sulfur transport. At physiological pH, cysteine undergoes rapid oxidation to form cystine. Reduced availability of cysteine or cystine, influences leukocyte metabolism. L-Cystine is necessary for oxygen production and LDL (low density lipoprotein) modification by arterial smooth muscle cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

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Studies on Analogues of L-Cysteine and L-Cystine
Austin S and Leif G
Blood (2018)
Mutation of Ataxia?Telangiectasia Mutated is Associated with Dysfunctional Glutathione Homeostasis in Cerebellar Astroglia
Andrew Campbell
Glia, 64(2), 227-239 (2016)
Transport Interaction of t-Cystine and L-Glutamate in Human Diploid
Fibroblasts in Culture
Shiro Bannai and Emi Kitamur
The Journal of Biological Chemistry, 255(6), 2372- 2376 (1980)
Using cysteine/cystine to overcome oxidative stress in goat oocytes and embryos cultured in vitro
Zhengrong Zhou
Molecular Medicine Reports, 14(2) (2016)
Distinguishing the cyanobacterial neurotoxin b-N-methylamino-L-alanine
(BMAA) from other diamino acids
S.A. Banack
Toxicon (2011)

Articoli

Importance and uses of cysteine in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

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