C2542
Monoclonal Anti-N-Cadherin antibody produced in mouse
clone GC-4, ascites fluid
Sinonimo/i:
Anti-A-CAM, Anti-A-Cell Adhesion Molecule
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About This Item
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
ascites fluid
Tipo di anticorpo
primary antibodies
Clone
GC-4, monoclonal
contiene
15 mM sodium azide
Reattività contro le specie
chicken, mouse, human, rabbit, rat
tecniche
electron microscopy: suitable
immunohistochemistry (frozen sections): 1:100 using chicken cardiac muscle
microarray: suitable
western blot: 1:100 using chicken or rat cardiac muscle
N° accesso UniProt
applicazioni
research pathology
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)
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Categorie correlate
Descrizione generale
N-cadherin is a calcium dependent cell adhesion molecule and is present mainly in cancer cells. Monoclonal anti-N-cadherin antibody reacts with the N-terminal portion of the extracellular domain of adipocyte adhesion molecule (ACAM).
Specificità
Monoclonal anti-N-cadherin antibody reacts specifically with A-CAM molecule in human, mouse, rabbit, chicken and rat.
Immunogeno
Affinity purified chicken heart A-CAM.
Applicazioni
Monoclonal anti-N-cadherin antibody can be used in immunofluorescent microscopy, electron microscopy and immunoblotting to study the receptor localization of intercellular adherens. It may also be used to study the mechanism of adhesion and interaction in tissues.
Monoclonal anti-N-cadherin antibody can be used in immunohistochemistry (1: 100) and as primary antibody in western blotting (1:1000) .
Azioni biochim/fisiol
N-cadherin regulates the Src kinase pathway and also promotes cell motility and invasion. It inhibits adherens junction formation and disrupts existing junctions of cultured lens cells.
Stato fisico
Monoclonal Anti-N-Cadherin antibody produced in mouse is supplied as ascites fluid containing 15mM sodium azide.
Stoccaggio e stabilità
For continuous use, store at 2-8 °C for up to one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Kamiel A J Kuijpers et al.
BioMed research international, 2014, 754596-754596 (2014-05-16)
The human bladder shows spontaneous autonomous activity. Detrusor overactivity could be seen as a consequence of exaggerated autonomous activity. Interstitial cells (ICs) play a potential role in coordination of autonomous activity. As it is suggested that changes in ICs coexist
Balázs Hegedüs et al.
Biophysical journal, 91(7), 2708-2716 (2006-07-11)
Impairment of tissue cohesion and the reorganization of the extracellular matrix are crucial events during the progression toward invasive cell phenotype. We studied the in vitro invasion patterns of nine brain tumor cell lines in three-dimensional collagen gels. Cell-cell and
Ignacio Ramis-Conde et al.
Physical biology, 6(1), 016008-016008 (2009-03-27)
Transendothelial migration is a crucial process of the metastatic cascade in which a malignant cell attaches itself to the endothelial layer forming the inner wall of a blood or lymph vessel and creates a gap through which it enters into
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis
Hazan RB
The Journal of cell biology, 148(4), 779-790 (2000)
Kamiel A J Kuijpers et al.
BioMed research international, 2014, 464217-464217 (2014-04-11)
Interstitial cells, also called myofibroblasts, most probably play a major role in the pathogenesis of the overactive bladder. However, no specific phenotypic marker has been identified. We investigated whether N-cadherin could play a role as a discriminatory marker for interstitial
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