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C001

Sigma-Aldrich

Acetylethylcholine mustard hydrochloride

>97% (GC), powder

Sinonimo/i:

Acetyl AF-64

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About This Item

Formula empirica (notazione di Hill):
C8H16ClNO2 · HCl
Numero CAS:
103994-00-9
Peso molecolare:
230.13
Numero MDL:
MFCD00055153
Codice UNSPSC:
12352200
ID PubChem:
329774756
NACRES:
NA.77

Saggio

>97% (GC)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

white

Punto di fusione

78-81  °C

Solubilità

H2O: >5 mg/mL
ethanol: soluble
methanol: soluble

Temperatura di conservazione

−20°C

Stringa SMILE

Cl[H].CCN(CCCl)CCOC(C)=O

InChI

1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H
CHWPASAPXMNLKO-UHFFFAOYSA-N

Applicazioni

Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function.

Azioni biochim/fisiol

Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM.
Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.
Acetylethylcholine mustard is an irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.

Avvertenza

Extremely hygroscopic.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Classi di pericolo

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3

Organi bersaglio

Nervous system, Respiratory system

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

204.8 °F - closed cup

Punto d’infiammabilità (°C)

96 °C - closed cup

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Certificati d'analisi (COA)

Lot/Batch Number
024M4617V
091M4609V
099K46081
099K4608
029K4614

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