B5386

8-Bromoadenosine 3′,5′-cyclic monophosphate

≥97% (HPLC), powder, protein kinase A activator

• Sinonimo/i: 8-Br-A-3:5-MP, 8-Br-cAMP, 8-Bromo-cAMP
• Formula empirica (notazione di Hill): C₁₀H₁₁BrN₅O₆P
• Numero CAS: 23583-48-4
• Peso molecolare: 408.10
• Beilstein: 591930
• Numero CE: 245-760-6
• Numero MDL: MFCD00075580
• Codice UNSPSC: 41106305
• ID PubChem: 24891835
• NACRES: NA.77

Proprietà

• Nome del prodotto: 8-Bromoadenosine 3′,5′-cyclic monophosphate, ≥97% (HPLC)
• Livello qualitativo: 200
• Saggio: ≥97% (HPLC)
• Stato: powder
• Punto di fusione: 254 °C (dec.) (lit.)
• Solubilità: aqueous base: soluble, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc12
• InChI: 1S/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1; DVKQVRZMKBDMDH-UUOKFMHZSA-N

Descrizione

Applicazioni

8-Bromoadenosine 3′,5′-cyclic monophosphate has been used:

• to treat H295R cells as positive controls for CYP19 induction
• as a membrane permeable cAMP analog to study its effect on short-circuit current (I_sc)
• to investigate its potential as an inducer of differentiation in Wharton′s jelly-derived mesenchymal stem cells (WJ-MSCs)

Azioni biochim/fisiol

8-Bromoadenosine 3′,5′-cyclic monophosphate is a cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. 8-Bromoadenosine 3′,5′-cyclic monophosphate activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

8-bromo-adenosine 3′,5′-cyclic monophosphate (8-bromo-cAMP), added to hepatocytes during plating helps to increase the acquisition of beta-adrenoceptors.

Caratteristiche e vantaggi

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Altre note

8-Bromoadenosine 3′,5′-cyclic monophosphate is a membrane-permeable cAMP analog.

Sensitive to light and moisture

Avvertenza

Sensitive to light and moisture.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)