A8986

Alexidine dihydrochloride

≥95% (HPLC)

• Sinonimo/i: 1,1′-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)
• Formula empirica (notazione di Hill): C₂₆H₅₆N₁₀ · 2HCl
• Numero CAS: 1715-30-6
• Peso molecolare: 581.71
• Numero CE: 216-994-6
• Numero MDL: MFCD00082369
• Codice UNSPSC: 12352200
• ID PubChem: 329771026
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to off-white
• Solubilità: DMSO: ≥10 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC
• InChI: 1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H; BRJJFBHTDVWTCJ-UHFFFAOYSA-N

Descrizione

Applicazioni

Alexidine dihydrochloride has been used:

• as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms
• as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on spare respiratory capacity and viability of CD8⁺ T cells
• as a PTPMT1 inhibitor to study its antiviral effect on  human cytomegalovirus (HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells

Azioni biochim/fisiol

Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer. Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity. Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution.

Alexidine dihydrochloride is a potent and selective PTPMT1 (Protein Tyrosine Phosphatase Localized to the Mitochondrion 1) inhibitor. Alexidine increases insulin secretion by isolated rat pancreatic islets.

Caratteristiche e vantaggi

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable