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A6563

Sigma-Aldrich

6-Anilinoquinoline-5,8-quinone

≥95% (TLC), solid

Sinonimo/i:

6-(Phenylamino)-5,8-quinolinedione, LY-83,583, LY83583

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About This Item

Formula empirica (notazione di Hill):
C15H10N2O2
Numero CAS:
91300-60-6
Peso molecolare:
250.25
Numero MDL:
MFCD00210756
Codice UNSPSC:
41106305
ID PubChem:
24891108
NACRES:
NA.77

Livello qualitativo

200

Saggio

≥95% (TLC)

Stato

solid

Colore

violet

Solubilità

0.1 M HCl: 1 mg/mL
methanol: 11 mg/mL
ethanol: 8 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1C=C(Nc2ccccc2)C(=O)c3cccnc13

InChI

1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
GXIJYWUWLNHKNW-UHFFFAOYSA-N

Applicazioni

6-Anilinoquinoline-5,8-quinone inhibits soluble guanylate cyclase and cGMP production. 6-Anilinoquinoline-5,8-quinone also blocks the release of intracellular Ca2+ and antigen-induced leukotrienes.

Azioni biochim/fisiol

Blocks cGMP production; inhibits intracellular Ca2+ release; blocks the effects of nitric oxide. Inhibits antigen-induced leukotriene release.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Rajendra Patel et al.
Journal of vascular surgery, 43(2), 364-371 (2006-02-16)
Smooth muscle cells (SMCs) from prosthetic vascular grafts secrete higher levels of collagen than aortic SMCs under basal conditions and during incubation with oxidized low-density lipoprotein. We postulated that reactive oxygen species (ROS) contributed to the observed difference. The objective
Amaury de Montaigu et al.
The Plant cell, 22(5), 1532-1548 (2010-05-06)
Nitrate assimilation in plants and related organisms is a highly regulated and conserved pathway in which the enzyme nitrate reductase (NR) occupies a central position. Although some progress has been made in understanding the regulation of the protein, transcriptional regulation
Vladimir A Snetkov et al.
Cardiovascular research, 89(1), 214-224 (2010-09-02)
the aim of this study was to determine the relative importance of Ca(2+) sensitization, ion channels, and intracellular Ca(2+) ([Ca(2+)](i)) in the mixed constrictor/relaxation actions of superoxide anion on systemic and pulmonary arteries. pulmonary and mesenteric arteries were obtained from
Greg A Knock et al.
Free radical biology & medicine, 46(5), 633-642 (2008-12-24)
Reactive oxygen species play a key role in vascular disease, pulmonary hypertension, and hypoxic pulmonary vasoconstriction. We investigated contractile responses, intracellular Ca(2+) ([Ca(2+)](i)), Rho-kinase translocation, and phosphorylation of the regulatory subunit of myosin phosphatase (MYPT-1) and of myosin light chain
I Fleming et al.
British journal of pharmacology, 103(1), 1047-1052 (1991-05-01)
1. The aim of this investigation was to study the relationship between contractile responsiveness, activation of the L-arginine pathway and tissue levels of guanosine 3':5'cyclic monophosphate (cylic GMP) in aortic rings removed from rats 4 h after intraperitoneal administration of
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