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A6476

Sigma-Aldrich

ABT-418 hydrochloride

powder, ≥98% (HPLC)

Sinonimo/i:

3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C9H14N2O · HCl
Numero CAS:
147388-83-8
Peso molecolare:
202.68
Numero MDL:
MFCD11045960
Codice UNSPSC:
51111800
ID PubChem:
24724395
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Solubilità

H2O: soluble 15 mg/mL

Ideatore

Abbott

Stringa SMILE

Cl.CN1CCC[C@H]1c2cc(C)no2

InChI

1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
VOXHERKWAIEJQF-QRPNPIFTSA-N

Descrizione generale

ABT-418 is an α4β2 agonist of nicotinic receptors.

Applicazioni

ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer′s disease.
ABT-418 hydrochloride has been used as a nicotinic acetylcholine receptor (nAChR) agonist to test its effect on spatial memory improvement in attention deficit hyperactivity disorder (ADHD) rat model

Azioni biochim/fisiol

Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330

Classi di pericolo

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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J D Brioni et al.
The Journal of pharmacology and experimental therapeutics, 271(1), 353-361 (1994-10-01)
The hydrochloride salt of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT-418), a potent activator of select subtypes of neuronal nicotinic acetylcholine receptors enhanced retention in memory tests and induced anxiolytic-like effects in mice in the elevated plus maze. In the present studies in rats
R Nikolov
Drug news & perspectives, 11(4), 248-255 (2004-12-24)
The 5th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy focused on new therapeutic approaches for the treatment of Alzheimer 's disease (AD) based on the latest basic science data. The two major pharmacological principles of cholinergic therapy are 1)
J D Brioni et al.
Psychopharmacology, 119(4), 368-375 (1995-06-01)
Previous studies have established that ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. A series of experiments was conducted to

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