A1908
Asialofetuin from fetal calf serum
Type II (Sigma designation)
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About This Item
Prodotti consigliati
Origine biologica
bovine
Livello qualitativo
Tipo
Type II (Sigma designation)
Stato
powder
tecniche
activity assay: suitable
inhibition assay: suitable
Impurezze
salt, essentially free
≤1.0% N-acetylneuraminic acid
Solubilità
H2O: soluble 1.0 mg/mL, clear to hazy, colorless to very faintly yellow
Temperatura di conservazione
2-8°C
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Applicazioni
Asialofetuin from fetal calf serum is suitable for use:
- in the assay of the lactose binding activity of the galectin-7 by immunodetection of in situ binding activity to asialofetuin immobilized on nitrocellulose
- in the inhibition of zona pellucida hardening of mouse oocytes
- as an acceptor in sialyltransferase enzyme activity assay
Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery to and endocytosis by cells displaying the AF receptor, notably hepatocytes. This provides a very efficient route for gene therapy.
Azioni biochim/fisiol
Asialofetuin (AF) binds to asialoglycoprotein receptor (ASGP-R) and is employed as a ligand for drug delivery to the hepatocytes. It aids serum-resistant lipoplexes for efficient gene deliver into the HepG2 (human hepatoblastoma) cells.
Feutins are glycoproteins that belong to the cystatin superfamily. They are characterized by the presence of two tandemly arranged cystatin-like domains and an unrelated domain. It binds to transforming growth factor (TGF)-β/BMP (bone morphogenic protein) cytokines.
Nota sulla preparazione
Enzymatic cleavage using neuraminidase
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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In vitro gene delivery mediated by asialofetuin-appended cationic liposomes associated with gamma-cyclodextrin into hepatocytes
Motoyama K, et al.
Journal of Drug Delivery, 2011 (2011)
X C Wang et al.
The Journal of biological chemistry, 264(3), 1854-1859 (1989-01-25)
The hepatic acute phase response is accompanied by increased levels of Gal beta 1-4GlcNAc alpha 2,6-sialyltransferase activity in liver and in circulation. Previous studies suggested that cytokines and glucocorticoids mediate the induction of this sialyltransferase activity. In this study the
Serum-resistant lipoplexes in the presence of asialofetuin
Liposomes, 2011, 425-434 (2010)
W M Brown et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 14(11), 749-755 (1992-11-01)
Bovine fetuin, the first fetal protein to be described, has recently been shown to be a species homologue of a well known human plasma protein--alpha 2HS glycoprotein (alpha 2HS). The fetuins are now known to be members of the cystatin
Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic.
Xinhua Lin et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 24(11), 2051-2058 (2006-08-22)
These studies evaluated whether F2A4-K-NS, a peptide mimetic of FGF-2, could augment ectopic bone production following the subcutaneous implant of human demineralized bone matrix (DBM). DBM was formulated into a gel with and without F2A4-K-NS, and injected subcutaneously into athymic
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