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A114

Sigma-Aldrich

(+)-N-Allylnormetazocine hydrochloride

≥98% (HPLC)

Sinonimo/i:

(+)-NANM hydrochloride, SKF-10047, SKF10047, [2S-(2α, 6α,11R*)]-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C17H23NO · HCl
Numero CAS:
133005-41-1
Peso molecolare:
293.83
Numero MDL:
MFCD00078552
Codice UNSPSC:
12352200
ID PubChem:
24278250
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Attività ottica

[α]21/D +90.6°, c = 1 in ethanol(lit.)

Controllo stupefacenti

regulated under CDSA - not available from Sigma-Aldrich Canada

Condizioni di stoccaggio

desiccated

Colore

white

Solubilità

H2O: >10 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

Cl[H].C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CC=C

InChI

1S/C17H23NO.ClH/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17;/h4-6,11-12,16,19H,1,7-10H2,2-3H3;1H/t12-,16+,17+;/m1./s1
ZTGMHFIGNYXMJV-XSCGHNKWSA-N

Informazioni sul gene

human ... OPRS1(10280)

Azioni biochim/fisiol

Selective σ1 receptor agonist.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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R A Wilke et al.
The Journal of biological chemistry, 274(26), 18387-18392 (1999-06-22)
Recent work has indicated that sigma receptor ligands can modulate potassium channels. However, the only sigma receptor characterized at the molecular level has a novel structure unlike any other receptor known to modulate ion channels. This 26-kDa protein has a
Parham Gharagozlou et al.
BMC pharmacology, 3, 1-1 (2003-01-07)
The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a cell system expressing only mu opioid receptors. Receptor activation was assessed by measuring the inhibition of forskolin-stimulated cyclic
Parham Gharagozlou et al.
BMC pharmacology, 6, 3-3 (2006-01-26)
The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse kappa-opioid receptors. Receptor activation was assessed by measuring
C Bucolo et al.
The Journal of pharmacology and experimental therapeutics, 289(3), 1362-1369 (1999-05-21)
In this study, we examined the presence of sigma1 and sigma2 sites in the rabbit iris-ciliary body by receptor binding and investigated their effects on intraocular pressure (IOP) in albino rabbits. The iris-ciliary body has binding sites for the sigma1-site
Parham Gharagozlou et al.
BMC neuroscience, 3, 19-19 (2002-11-20)
The aim of the present study was to characterize the activation profiles of 15 opioid ligands in transfected human embryonic kidney cells expressing only delta opioid receptors. Activation profiles of most of these ligands at delta opioid receptors had not
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