A0885

Aurintricarboxylic acid ammonium salt

powder

• Sinonimo/i: ATA, Aluminon, Ammonium aurintricarboxylate
• Formula condensata: C₂₂H₁₄O₉ · 3NH₃
• Numero CAS: 569-58-4
• Peso molecolare: 473.43
• Colour Index: 43810
• Beilstein: 3900820
• Numero CE: 209-319-1
• Numero MDL: MFCD00040925
• Codice UNSPSC: 12171500
• ID PubChem: 24890465
• NACRES: NA.47

Proprietà

• Origine biologica: synthetic
• Forma fisica: powder
• Colore: dark red
• Punto di fusione: 220-225 °C (dec.) (lit.)
• Solubilità: water: soluble 100 mg/mL, dark red
• λmax: 552 nm (λmax: )
• applicazioni: diagnostic assay manufacturing; hematology; histology
• Temperatura di conservazione: room temp
• Stringa SMILE: N.N.N.OC(=O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O)=O)=C3/C=CC(=O)C(=C3)C(O)=O
• InChI: 1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3; AIPNSHNRCQOTRI-UHFFFAOYSA-N

Descrizione

Applicazioni

Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.

Azioni biochim/fisiol

Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.

Altre note

May contain a substantial amount of polymeric material.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves