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Key Documents

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75903

Sigma-Aldrich

Guanosine

≥97.0% (HPLC)

Sinonimo/i:

9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside

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About This Item

Formula empirica (notazione di Hill):
C10H13N5O5
Numero CAS:
118-00-3
Peso molecolare:
283.24
Beilstein:
625911
Numero CE:
204-227-8
Numero MDL:
MFCD00010182
Codice UNSPSC:
41106305
ID PubChem:
329766751
NACRES:
NA.51

Livello qualitativo

200

Saggio

≥97.0% (HPLC)

Forma fisica

powder

Attività ottica

[α]20/D -73±2°, c = 1.5% in 1 M NaOH

Impurezze

≤6.0% water

Punto di fusione

250 °C (dec.) (lit.)

Stringa SMILE

[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
NYHBQMYGNKIUIF-UUOKFMHZSA-N

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Applicazioni

Guanosine is a purine nucleoside that upon sequential phosphoylation (kinases) forms GTP which is used by RNA polymerases to synthesis RNA(s). GTP is also important in a wide range of GTPase-dependent cell signaling processes. Guanosine is used in selective matricies such a guanosine gels (G-gels) for use in capillary electrophoresis chiral selection and other applications.

Altre note

Currently available only in Europe.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Inosine ≥99% (HPLC)

Sigma-Aldrich

I4125

Inosine

Xanthosine dihydrate ≥99%

Sigma-Aldrich

X0750

Xanthosine dihydrate

Adenosine European Pharmacopoeia (EP) Reference Standard

A0230200

Adenosine

Adenosine

Sigma-Aldrich

01890

Adenosine

8-Hydroxy-2′-deoxyguanosine ≥98% (TLC)

Sigma-Aldrich

H5653

8-Hydroxy-2′-deoxyguanosine

Hypoxanthine ≥99.0%

Sigma-Aldrich

H9377

Hypoxanthine

Timidina ≥99.0% (HPLC)

Sigma-Aldrich

89270

Timidina

Guanine 98%

Sigma-Aldrich

G11950

Guanine

Nadine Gehrke et al.
Immunity, 39(3), 482-495 (2013-09-03)
Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base
Jérémie Piton et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8858-8863 (2013-04-24)
The initiation of mRNA degradation often requires deprotection of its 5' end. In eukaryotes, the 5'-methylguanosine (cap) structure is principally removed by the Nudix family decapping enzyme Dcp2, yielding a 5'-monophosphorylated RNA that is a substrate for 5' exoribonucleases. In
Zoran D Matović et al.
Journal of inorganic biochemistry, 121, 134-144 (2013-02-05)
Novel square-planar palladium(II) complexes with O-N-N-O-type ligands H4mda (H4mda=malamido-N,N'-diacetic acid) and H4obp (H4obp=oxamido-N,N'-di-3-propionic acid) were prepared and characterized. The ligands coordinate to the palladium(II) ion via two pairs of deprotonated ligating atoms with square chelation. A four coordinate, square-planar geometry
Zhe Li et al.
Nucleic acids research, 42(6), 4068-4079 (2013-12-29)
G-quadruplex-forming oligonucleotides containing modified nucleotide chemistries have demonstrated promising pharmaceutical potential. In this work, we systematically investigate the effects of sugar-modified guanosines on the structure and stability of a (4+0) parallel and a (3+1) hybrid G-quadruplex using over 60 modified
Jeffery T Davis et al.
Chemical Society reviews, 36(2), 296-313 (2007-02-01)
Nature's use of a simple genetic code to enable life's complex functions is an inspiration for supramolecular chemistry. DNA nucleobases carry the key information utilizing a variety of cooperative and non-covalent interactions such as hydrophobic, van der Waals, pi-pi stacking
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