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Key Documents

54702

Sigma-Aldrich

FITC–DEAE–Dextran

average mol wt 70,000

Sinonimo/i:

FITC–DEAE–Dextran 70, Fluorescein isothiocyanate–Diethylaminoethyl–Dextran

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About This Item

Codice UNSPSC:
12352108
NACRES:
NA.32

Origine biologica

synthetic

Livello qualitativo

100

Coniugato

FITC conjugate

Forma fisica

powder or crystals

PM

average mol wt 70,000

Composizione

nitrogen content, 2-5%

Grado di funzionalizzazione

0.001-0.020 mol/mol FITC glucose

tecniche

permeability assay: suitable

Fluorescenza

λex 493 nm; λem 518 nm in 0.1 M Tris pH 8.0

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Applicazioni

FITC-DEAE-Dextran 70 is a cationic fluorescent dextran that may be used to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC-DEAE-Dextran 70 may be use to compare its selectivity versus neutral FITC-Dextran 70 or anionic FITC-CM-Dextran 70.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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J K Leypoldt et al.
Kidney international, 43(4), 837-844 (1993-04-01)
The influence of molecular charge on macromolecule transport during peritoneal dialysis was assessed by determining transperitoneal transport rates for fluorescent-labeled macromolecules (molecular radii from 15 to 40 A) that differed only in molecular charge: neutral dextran, anionic dextran sulfate and
Mary C Regier et al.
Scientific reports, 9(1), 6433-6433 (2019-04-25)
Concentration gradients of biochemical stimuli such as morphogens play a critical role in directing cell fate patterning across species and throughout development but are not commonly recapitulated in vitro. While in vitro biomolecule gradients have been generated using customized microfluidic
Reduced diffusion of charge-modified, conformationally intact anionic Ficoll relative to neutral Ficoll across the rat glomerular filtration barrier in vivo.
Axelsson J, Sverrisson K, Rippe A, et al.
American Journal of Physiology: Renal Physiology, 301, F708-F712 (2011)
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)

Articoli

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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