434R-1
ERG (EP111) Rabbit Monoclonal Primary Antibody
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
100
500
Coniugato
unconjugated
Forma dell’anticorpo
culture supernatant
Tipo di anticorpo
primary antibodies
Clone
EP111, monoclonal
Descrizione
(For In Vitro Diagnostic Use in Select Regions (See Chart))
Stato
buffered aqueous solution
Reattività contro le specie
human
Confezionamento
vial of 0.1 mL concentrate (434R-14)
vial of 0.5 mL concentrate (434R-15)
bottle of 1.0 mL predilute (434R-17)
vial of 1.0 mL concentrate (434R-16)
bottle of 7.0 mL predilute (434R-18)
Produttore/marchio commerciale
Cell Marque™
tecniche
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
Isotipo
IgG
Controllo
tonsil
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
Visualizzazione
nuclear
Informazioni sul gene
human ... ERG(2078)
Categorie correlate
Descrizione generale
ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.1 ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.1 ERG has also been observed to be positive in a minority of Ewing sarcomas.2 This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).5 ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.1
Qualità
 IVD |  IVD |  IVD |  RUO |
Linkage
ERG Positive Control Slides, Product No. 434S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Stato fisico
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Nota sulla preparazione
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Altre note
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Note legali
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Oksana Yaskiv et al.
American journal of clinical pathology, 138(6), 803-810 (2012-11-20)
Avian v-ets erythroblastosis virus E26 oncogene homolog (ERG) is highly sensitive and specific for endothelial neoplasms and specific for prostate carcinoma. We characterized a rabbit anti-ERG antibody as an immunohistochemical agent to detect ERG expression in various tumors using tissue
J R Bänffer et al.
Antonie van Leeuwenhoek, 53(3), 183-190 (1987-01-01)
The immune response was studied in 238 human patients with Campylobacter jejuni/coli (CJC)-infections in Rotterdam by the counterimmunoelectrophoresis (CIE) test, a commercial complement fixation test (CFT) and the passive haemagglutination test (HA). Antibodies became detectable in the three tests around
Jason L Hornick
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27 Suppl 1, S47-S63 (2014-01-05)
Immunohistochemistry plays a key role in the diagnosis of soft tissue tumors. Until recently, however, the primary purpose of immunohistochemistry in this context was simply to attempt to demonstrate a line of differentiation. Unfortunately, most traditional markers (predominantly directed against
Sarah Minner et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(1), 106-116 (2012-08-18)
Approximately 50% of prostate cancers are characterized by TMPRSS2 (transmembrane protease serine 2)-ERG (avian v-ets erythroblastosis virus E26 oncogene homolog) gene fusions resulting in an androgen-regulated overexpression of the transcription factor ERG. Some studies have suggested prognostic or predictive relevance
Markku Miettinen et al.
The American journal of surgical pathology, 35(3), 432-441 (2011-02-15)
ERG, an ETS family transcription factor, is known to be expressed in endothelial cells, and oncogenic ERG gene fusions occur in subsets of prostatic carcinoma, acute myeloid leukemia, and Ewing sarcoma. In this study, we immunohistochemically investigated nuclear ERG expression
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