321R-2

PLAP (EP194) Rabbit Monoclonal Primary Antibody

• Sinonimo/i: Placental Alkaline Phosphatase
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: EP194, monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (321R-24); vial of 0.1 mL concentrate Research Use Only (321R-24-RUO); vial of 0.5 mL concentrate (321R-25); vial of 1.0 mL concentrate (321R-26); vial of 1.0 mL concentrate Research Use Only (321R-26-RUO); vial of 1.0 mL pre-dilute Research Use Only (321R-27-RUO); vial of 1.0 mL pre-dilute ready-to-use (321R-27); vial of 7.0 mL pre-dilute ready-to-use (321R-28); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (321R-28-RUO)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• Isotipo: IgG
• Controllo: placenta
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: cytoplasmic
• Informazioni sul gene: human ... ALPP(250)

Descrizione

Descrizione generale

Placental alkaline phosphatase (PLAP) is normally produced by primordial germ cells and syncytiotrophoblasts, and the detection of its expression has been useful in identifying germ cell tumors. Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. Complete hydatidiform mole shows strong expression of hCG and weak expression of PLAP. Weak hCG and strong PLAP expression is found in partial hydatidiform mole. Choriocarcinoma presents strong expression of hCG and weak expression of hPL and PLAP.8 In addition to its role as a germ cell marker, PLAP may also be used as a myogenic marker in identifying soft tissue tumors.

Qualità

IVD

IVD

IVD

RUO

Linkage

PLAP Positive Control Slides, Product No. 321S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable