201M-9
Actin, Muscle Specific (HHF35) Mouse Monoclonal Antibody
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
100
500
Coniugato
unconjugated
Forma dell’anticorpo
culture supernatant
Tipo di anticorpo
primary antibodies
Clone
HHF35, monoclonal
Descrizione
For In Vitro Diagnostic Use in Select Regions (See Chart)
Stato
buffered aqueous solution
Reattività contro le specie
human
Confezionamento
vial of 0.1 mL concentrate (201M-94)
vial of 0.5 mL concentrate (201M-95)
bottle of 1.0 mL predilute (201M-97)
vial of 1.0 mL concentrate (201M-96)
bottle of 7.0 mL predilute (201M-98)
Produttore/marchio commerciale
Cell Marque™
tecniche
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
Isotipo
IgG1κ
Controllo
skeletal muscle
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
Visualizzazione
cytoplasmic
Categorie correlate
Descrizione generale
Mucins are a diverse group of complex, highly glycosylated extracellular proteins. Mucin 2 (MUC2) protects the gastric and intestinal epithelium from chemical and mechanical injury. Anti-MUC2 reactivity is normally seen in goblet cells of the small intestine and colon and is associated with mucinous carcinomas, including those of the gastrointestinal tract and ovary. MUC2 immunohistochemistry is useful for identifying colonic, gastric, and esophageal carcinomas.
Muscle Specific Actin is a part of the actin family of proteins which are highly conserved, major components of the cytoskeleton. Anti-Muscle Specific Actin immunohistochemical reactivity is seen in skeletal, cardiac, and smooth muscle cells and can be seen in neoplasms with muscle differentiation such as leiomyomas and rhabdomyosarcomas. In contrast, anti-Muscle Specific Actin reactivity is typically not seen in endothelial cells, connective tissues, carcinomas, melanomas, lymphomas, and most non-myogenic sarcomas.
Qualità
 IVD |  IVD |  IVD |  RUO |
Linkage
Actin, Muscle Specific Positive Control Slides, Product No. 201S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Stato fisico
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Nota sulla preparazione
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Altre note
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Note legali
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
R A Schmidt et al.
The American journal of pathology, 131(1), 19-28 (1988-04-01)
The authors have recently developed a monoclonal antibody, HHF35, that recognizes the muscle-specific isoforms of actin. To determine its potential usefulness in the differential diagnosis of "small, round, blue cell" tumors of childhood, they immunolabeled formalinor B-5-fixed tissue sections from
N Azumi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1(6), 469-474 (1988-11-01)
Two fibrillary proteins, muscle-specific actin (MSA) and desmin, are found only in cells of smooth and skeletal muscle lineages. Among the monoclonal antibodies (MAbs) to these antigens which we have tested, we found several to be reactive in formalin-fixed, paraffin-embedded
Comparative immunohistochemical staining for desmin and muscle-specific actin. A study of 576 cases.
S Rangdaeng et al.
American journal of clinical pathology, 96(1), 32-45 (1991-07-01)
Muscle-specific actin (MSA) and desmin are considered to be sensitive and specific markers for muscle differentiation. The authors compared staining patterns for these markers in 576 samples of normal, reactive, and neoplastic tissues. The standard avidin-biotin-peroxidase complex technique was performed
T Tsukada et al.
The American journal of pathology, 127(2), 389-402 (1987-05-01)
Monoclonal antibody HHF35 has previously been characterized biochemically as recognizing isotypes of actin (alpha and gamma) which are specific to muscle cells. In this study, the authors have investigated the normal and pathologic tissue distribution of HHF35-positive cells using the
A M Gown et al.
The American journal of pathology, 125(1), 191-207 (1986-10-01)
The authors have performed immunocytochemical investigations of the distribution of various cell types in human atherosclerotic plaques using monoclonal antibodies specific to smooth muscle cells (CGA7 [Gown et al, J Cell Biol 1985, 100:807-813] and HHF35 [Tsukada et al, Am
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