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Sigma-Aldrich

Acetonitrile

≥99.9%, gradient grade, suitable for UV/Vis spectroscopy, HPLC

Sinonimo/i:

ACN, Cianometano, Cianuro di metile, Etilnitrile

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About This Item

Formula condensata:
CH3CN
Numero CAS:
Peso molecolare:
41.05
Beilstein:
741857
Numero CE:
Numero MDL:
Codice UNSPSC:
12190000
ID PubChem:
NACRES:
NA.03

product name

Acetonitrile, suitable for HPLC, gradient grade, ≥99.9%

Grado

gradient grade

Livello qualitativo

Densità del vapore

1.41 (vs air)

Tensione di vapore

72.8 mmHg ( 20 °C)

Descrizione

HPLC gradient analysis <= 0.5 mAU @254 nm
HPLC gradient analysis <= 3 mAU @ 210 nm
baseline drift at 210 nm <= 15 mAU

Saggio

≥99.9%

Forma fisica

liquid

Temp. autoaccensione

973 °F

Purificato mediante

sub-micron filtration

Limite di esplosione

16 %

tecniche

HPLC: suitable
UV/Vis spectroscopy: suitable

Impurezze

≤0.0002% free alkali (as NH3)
≤0.001% free acid (as CH3COOH)
≤0.01% water (Karl Fischer)
≤0.5 ppb quinine fluor., 365 nm
≤1 ppb quinine fluor., 254 nm

Residuo dopo evaporazione

<0.0002%

Indice di rifrazione

n20/D 1.344 (lit.)

P. eboll.

81-82 °C (lit.)

Punto di fusione

−45 °C (lit.)

Solubilità

water: soluble

Densità

0.786 g/mL at 25 °C (lit.)

λ

H2O reference

Assorbanza UV

λ: 195 nm Amax: ≤0.12
λ: 200 nm Amax: ≤0.032
λ: 230 nm Amax: ≤0.0044

applicazioni

food and beverages

Formato

neat

Stringa SMILE

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3
WEVYAHXRMPXWCK-UHFFFAOYSA-N

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Descrizione generale

Acetonitrile (MeCN), an aliphatic nitrile, is a colorless liquid with a pleasant odor. It is widely used as a solvent and intermediate in organic syntheses. It is transparent to UV-visible light making it highly applicable in spectrophotometric and fluorimetric techniques. As MeCN has low viscosity, high elution strength and is highly miscible in water, it is utilized as a mobile phase component in many chromatographic techniques. Its infrared spectrum has been recorded. Synthesis of alkyl hydroperoxides in MeCN by alkane oxidation with hydrogen peroxide in the presence of iron complexes has been studied. The hydrogenation of MeCN to form ethylamine using Co–B amorphous alloy catalyst has been investigated.

Applicazioni


  • Chromatographic Separation of Anthocyanins: Acetonitrile is a preferred solvent in high-performance liquid chromatography (HPLC) for the separation of anthocyanins and other phenolic compounds. Studies have explored the selectivity control of anthocyanin separation by replacing acetonitrile with methanol in the mobile phase, highlighting the solvent′s role in optimizing chromatographic conditions for improved resolution and detection sensitivity (Deineka et al., Journal of Analytical Chemistry, 2021).

  • Peroxyoxalate Chemiluminescence Detection: Acetonitrile is used in peroxyoxalate chemiluminescence for the detection of α-amino acids. The solvent′s ability to form stable mixed solutions with water and ethyl acetate enhances the chemiluminescence reaction, allowing for sensitive and selective detection of amino acids in various samples. This application is essential for biochemical and clinical analyses (Kan et al., American Journal of Analytical Chemistry, 2020).

  • Electrochemical Detection of DNA Modifications: Acetonitrile is utilized in electrochemical methods for detecting DNA modifications, such as 5-formyluracil. The solvent′s role in stabilizing the (2-benzimidazolyl) acetonitrile labeling reaction enhances the selectivity and sensitivity of detecting DNA modifications, which is crucial for genomic and biomedical research (Tang et al., Analytical Chemistry, 2021).

  • Alternative Solvent in Chromatography: Research has investigated replacing acetonitrile with ethanol in reversed-phase HPLC for determining anthocyanins. This substitution aims to maintain chromatographic performance while reducing the environmental impact and costs associated with acetonitrile use. The findings demonstrate the feasibility of using ethanol as a greener alternative without compromising analytical quality (Deineka et al., Journal of Analytical Chemistry, 2023).


Nota sulla preparazione

Product filtered through a 0.2 μm filter

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Pittogrammi

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Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

35.6 °F - closed cup

Punto d’infiammabilità (°C)

2.0 °C - closed cup


Certificati d'analisi (COA)

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H Haugen et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 73(2), 229-237 (2005-03-10)
This article deals with enzyme-induced biodegradation behavior of thermoplastic polyether-urethane (TPU). Porous scaffolds were processed by a new foaming method applied in hot pressing and injection molding. The scaffolds were subsequently gamma sterilized. The samples were incubated with cholesterol esterase
Infrared spectra of acetonitrile and acetonitrile-d3.
Pace EL and Noe LJ.
J. Chem. Phys., 49, 5317-5325 (1968)
Liquid phase hydrogenation of acetonitrile to ethylamine over the Co-B amorphous alloy catalyst.
Li H, et al.
J. Catal., 214(1), 15-25 (2003)
Hydrogen peroxide oxygenation of alkanes including methane and ethane catalyzed by iron complexes in acetonitrile.
Shul'pin GB, et al.
Advanced Synthesis & Catalysis, 346(2-3), 317-332 (2004)
Eagleson M.
Concise Encyclopedia Chemistry, 6-6 (1994)

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