319988

Cloroformio

contains ethanol as stabilizer, ACS reagent, ≥99.8%

• Sinonimo/i: Triclorometano, Tricloruro di metilidina
• Formula empirica (notazione di Hill): CHCl₃
• Numero CAS: 67-66-3
• Peso molecolare: 119.38
• Beilstein: 1731042
• Numero MDL: MFCD00000826
• Codice UNSPSC: 12191502
• ID PubChem: 329753942
• NACRES: NA.21

Proprietà

• Grado: ACS reagent
• Livello qualitativo: 200
• Densità del vapore: 4.1 (vs air)
• Tensione di vapore: 160 mmHg ( 20 °C)
• Saggio: ≥99.8%
• Stato: liquid
• contiene: ethanol as stabilizer
• dilution: (for analytical testing)
• Impurezze: Acetone and aldehyde, passes test; Acid and chloride, passes test; Free chlorine (Cl), passes test; H₂SO₄, passes test
• Residuo dopo evaporazione: ≤0.001%
• Colore: APHA: ≤10
• Indice di rifrazione: n20/D 1.445 (lit.)
• P. ebollizione: 60.5-61.5 °C (lit.)
• Punto di fusione: −63 °C (lit.)
• Densità: 1.48 g/mL at 25 °C; 1.492 g/mL at 25 °C (lit.)
• Cationi in tracce: Pb: ≤0.05 ppm
• Temperatura di conservazione: room temp
• Stringa SMILE: ClC(Cl)Cl
• InChI: 1S/CHCl3/c2-1(3)4/h1H; HEDRZPFGACZZDS-UHFFFAOYSA-N

Descrizione

Descrizione generale

Chloroform, a halogenated hydrocarbon, is widely used as a solvent and extractant in various manufacturing and laboratory procedures. It can be produced by the chlorination of methane or lower-chlorinated methanes. Additionally, it is employed in the production of dichlorocarbenes, α-trichloromethyl carbinols, and trichlorolithiocarbenoids.

Applicazioni

Chloroform can be used as a solvent in the:

• Enzyme-catalyzed ring-opening polymerization of ω-pentadecalactone to prepare polyesters.
• Pd-catalyzed cross-coupling reaction of acid chlorides with arylboronic acids to synthesize diaryl Ketones.
• Enantio- and diastereoselective nitro-Mannich reaction of α-aryl nitromethanes with amido sulfones to synthesize β-nitroamines.
• Diels-Alder reaction to synthesize spiro-fused dihydropyans. The hydrogen bond (CH-O) formed between chloroform and carbonyl oxygen makes the carbonyl group a stronger heterodienophile, resulting in an increased reaction rate.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H315,H319,H331,H336,H351,H361d,H372
• Consigli di prudenza: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Organi bersaglio: Central nervous system, Liver,Kidney
• Codice della classe di stoccaggio: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): does not flash
• Punto d’infiammabilità (°C): does not flash