Y0001790

Thiocolchicoside crystallised from ethanol

European Pharmacopoeia (EP) Reference Standard

• Sinonimo/i: Thiocolchicoside, (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• Formula empirica (notazione di Hill): C₂₇H₃₃NO₁₀S
• Numero CAS: 602-41-5
• Peso molecolare: 563.62
• Numero MDL: MFCD07995056
• Codice UNSPSC: 41116107
• ID PubChem: 329831574
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: thiocolchicoside
• Produttore/marchio commerciale: EDQM
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1; LEQAKWQJCITZNK-AXHKHJLKSA-N

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Thiocolchicoside crystallised from ethanol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H341,H361fd,H372
• Consigli di prudenza: P201 - P301 + P310 + P330
• Classi di pericolo: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Organi bersaglio: Gastro-intestinal system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable