SMB00947
N-Desethyl amodiaquine dihydrochloride
≥95%
Sinonimo/i:
Monodesethylamodiaquine dihydrochloride
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About This Item
Formula empirica (notazione di Hill):
C18H18ClN3O · 2HCl
Numero CAS:
Peso molecolare:
400.73
Codice UNSPSC:
41116107
NACRES:
NA.77
Prodotti consigliati
Origine biologica
synthetic
Livello qualitativo
Saggio
≥95%
Forma fisica
solid
PM
400.73 g/mol
tecniche
HPLC: suitable
Colore
yellow to dark yellow
Solubilità
DMSO: soluble
methanol: soluble
water: soluble
Temperatura di conservazione
2-8°C
Applicazioni
Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.
Metabolomics research
Altre note
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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