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Key Documents

PHR1751

Supelco

Guanfacine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

Guanfacine hydrochloride, N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide

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About This Item

Formula empirica (notazione di Hill):
C9H9Cl2N3O · HCl
Numero CAS:
Peso molecolare:
282.55
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to USP 1302101

Famiglia di API

guanfacine

CdA

current certificate can be downloaded

Confezionamento

pkg of 500 mg

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl

InChI

1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
DGFYECXYGUIODH-UHFFFAOYSA-N

Informazioni sul gene

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Descrizione generale

Guanfacine hydrochloride, is a selective α-adrenergic receptor agonist, that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

Guanfacine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Azioni biochim/fisiol

α-2 noradrenergic receptor agonist.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC3708 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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Guanfacine hydrochloride
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 45(3), 2133-2133 (2018)
Guanfacine and secondary mania in children
Horrigan JP and Barnhill LJ
Journal of Affective Disorders, 54(3), 309-314 (1999)
Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods
Wahbi AM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 11(8), 639- 645 (1993)
L A Cornish
Clinical pharmacy, 7(3), 187-197 (1988-03-01)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of guanfacine hydrochloride are reviewed. Guanfacine lowers blood pressure by activating CNS alpha adrenoreceptors, which results in sympathetic outflow leading to reduced vascular tone. However, initial hypotensive response to guanfacine may

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