PHR1587

Thimerosal

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: Acido 2-(etilmercurio-mercapto)benzoico, Acido etilmercurio-tiosalicilico, Mercurio-([o-carbossifenil]tio)etil, Sodio etilmercurio-tiosalicilato
• Formula condensata: 2-(C₂H₅HgS)C₆H₄CO₂Na
• Numero CAS: 54-64-8
• Peso molecolare: 404.81
• Beilstein: 8169555
• Numero CE: 200-210-4
• Numero MDL: MFCD00013062
• Codice UNSPSC: 41116107
• ID PubChem: 329823493
• NACRES: NA.24

Proprietà

• Grado: certified reference material; pharmaceutical secondary standard
• Livello qualitativo: 300
• agenzia: traceable to Ph. Eur. Y0000109; traceable to USP 1659000
• Famiglia di API: thimerosal
• CdA: current certificate can be downloaded
• Confezionamento: pkg of 1 g
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Punto di fusione: 234-237 °C (dec.) (lit.)
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: 2-30°C
• Stringa SMILE: [Na+].CC[Hg]Sc1ccccc1C([O-])=O
• InChI: 1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2; RTKIYNMVFMVABJ-UHFFFAOYSA-L

Descrizione

Descrizione generale

Thimerosal belongs to the group of alkyl mercury compounds. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Applicazioni

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Thimerosal may be used as a pharmaceutical reference standard for the quantification of the analyte in ophthalmic solutions using spectrophotometric technique.

Azioni biochim/fisiol

Il thimerosal è un reagente ossidante (tiolo) sulfidrilico in grado di inibire un′ampia varietà di proteine ed enzimi sulfidril-dipendenti, quali la metionina sintasi dipendente da PI3-chinasi, i recettori per il trasporto del glutammato e le ATPasi dipendenti da Na⁺+K⁺.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA6959 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Esclusione di responsabilità

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310 + H330,H373,H410
• Consigli di prudenza: P262 - P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classi di pericolo: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral
• Organi bersaglio: Kidney
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable