92360

Chlorotrimethylsilane

puriss., ≥99.0% (GC)

• Sinonimo/i: TMCS, Trimethylchlorosilane, Trimethylsilyl chloride
• Formula condensata: (CH₃)₃SiCl
• Numero CAS: 75-77-4
• Peso molecolare: 108.64
• Beilstein: 1209232
• Numero CE: 200-900-5
• Numero MDL: MFCD00000502
• Codice UNSPSC: 12352101
• ID PubChem: 329770119
• NACRES: NA.22

Proprietà

• Densità del vapore: 3.7 (vs air)
• Livello qualitativo: 200
• Tensione di vapore: 100 mmHg ( 25 °C)
• Grado: puriss.
• Saggio: ≥99.0% (GC)
• Stato: liquid
• Temp. autoaccensione: 752 °F
• Limite di esplosione: 6.4 %
• Indice di rifrazione: n20/D 1.387 (lit.)
• P. ebollizione: 57 °C (lit.)
• Punto di fusione: −40 °C (lit.)
• Densità: 0.856 g/mL at 25 °C (lit.)
• Stringa SMILE: [H][C@@]12CC(C)(C)CC[C@]1(C)CC[C@]3(C)C2=CC[C@]4([H])[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C; C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3; IJOOHPMOJXWVHK-UHFFFAOYSA-N

Descrizione

Descrizione generale

Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.

Applicazioni

• Chlorotrimethylsilane can be a non-toxic alternative to mercuric chloride as activator in samarium-promoted cyclopropanation of both allylic and α-allenic alcohols.
• It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation.
• It is employed in chloromethylation of polysulfones (PSUs).
• It activates lithium hydride to convert it into a hydride source for the reductive silylation of carbonyl compounds.
• Chlorotrimethylsilane/lithium bromide forms an effective reagent for the conversion of alcohols to bromides.
• Chlorotrimethylsilane/sodium iodide in acetonitrile is a better alternative to iodotrimethylsilane for the cleavage of esters, lactones, carbamates, and ethers. It can also be used for the conversion of alcohols to iodides.
• Chlorotrimethylsilane along with silver or ammonium nitrate forms an efficient regioselective nitrating reagent for the ipso-nitration of arylboronic acids to form the corresponding nitroarenes.
• Chlorotrimethylsilane along with sodium nitrite or nitrate can be used for deoximation reactions.

Altre note

Silylating agent

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H331,H312,H314
• Consigli di prudenza: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Rischi supp: EUH014
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): -18.4 °F - closed cup
• Punto d’infiammabilità (°C): -28 °C - closed cup
• Dispositivi di protezione individuale: Faceshields, Gloves, Goggles