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29992

DL-α-Tocopherol acetate

Name: <SC>DL</SC>-α-Tocopherol acetate
Brand: SIAL

tested according to Ph. Eur.

Sinonimo/i:

α-Tocopherylis acetas, Vitamin E acetate, all-rac-α-Tocopheryl acetate

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About This Item

Formula empirica (notazione di Hill):

C₃₁H₅₂O₃

Numero CAS:

7695-91-2

Peso molecolare:

472.74

Beilstein:

97512

Numero CE:

231-710-0

Numero MDL:

MFCD00072042

Codice UNSPSC:

12352209

ID PubChem:

329753404

NACRES:

NA.26

Origine biologica

synthetic

Livello qualitativo

200

agenzia

USP/NF
tested according to Ph. Eur.

Saggio

96.5-102.0%

Forma fisica

liquid

Densità

0.96 g/mL at 20 °C (lit.)

applicazioni

cell analysis
pharmaceutical (small molecule)

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1
ZAKOWWREFLAJOT-CEFNRUSXSA-N

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Categorie correlate

Coenzimi

Vitamine

Descrizione generale

α-Tocopherol is a form of vitamin E. Vitamin E can be obtained through dietary sources. RRR‐α‐tocopherol is a natural form of α-Tocopherol.

Applicazioni

DL-alpha-Tocopherol acetate was used as a vitamin E supplement for studying whether the addition of an antioxidant or vitamin E in the diet of rats with dextran sulfate sodium (DSS)-induced colitis can reduce detrimental impact of inflammatory bowel disease.

Azioni biochim/fisiol

α-Tocopherol is also known as a radical-chain breaker due to its anti-oxidant property.

Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homosapiens. DL-α-Tocopherol acetate can inhibit oxidation of linoleate.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

No data available

Punto d’infiammabilità (°C)

No data available

Dispositivi di protezione individuale

Eyeshields, Gloves

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alpha-Tocopherol stereoisomers

Jensen S K and Lauridsen C

Vitamins and Hormones, 76(3), 281-308 (2007)

Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis.

Julie Carrier et al.

The Journal of nutrition, 132(10), 3146-3150 (2002-10-09)

Inflammatory bowel disease is often associated with iron deficiency anemia and oral iron supplementation may be required. However, iron may increase oxidative stress through the Fenton reaction and thus exacerbate the disease. This study was designed to determine in rats

New aspects of the inhibition of soybean lipoxygenase by alpha-tocopherol. Evidence for the existence of a specific complex.

S Grossman et al.

The International journal of biochemistry, 16(3), 281-289 (1984-01-01)

The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol. The alpha-tocopherol--lipoxygenase complex did not dissociate on addition of linoleic acid. Iodoacetate modified immobilized lipoxygenase did not form the complex with alpha-tocopherol. Lipoxygenase attached to

Molecular mechanism of alpha-tocopherol action

Azzi A

Free radical biology & medicine, 43(1), 16-21 (2007)

Absorption, transport, and tissue delivery of vitamin E

Rigotti A

Molecular Aspects of Medicine, 28(5-6), 423-436 (2007)

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Articoli

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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