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Key Documents

03716

Supelco

(±)-Lisofylline

analytical standard

Sinonimo/i:

Lisofylline, (±)-1-(5-Hydroxyhexyl)-3,7-dimethylxanthine, 5-Hydroxy pentoxifylline, Penthydroxyfylline

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About This Item

Formula empirica (notazione di Hill):
C13H20N4O3
Numero CAS:
Peso molecolare:
280.32
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥99.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

−20°C

Stringa SMILE

O=C1N(CCCCC(O)C)C(N(C)C2=C1N(C)C=N2)=O

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
NSMXQKNUPPXBRG-UHFFFAOYSA-N

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Descrizione generale

Lisofylline (LSF) is a synthetically modified methylxanthine which is known to exhibit various therapeutic properties. It is a potent anti-inflammatory agent and an antioxidant with the ability to suppress oxygen radical production. LSF is used for treating acute lung injury and also has a role in the early treatment of diabetes.

Applicazioni

Lisofylline may be used as an analytical reference standard for the determination of the analyte in rat plasma by various high-performance liquid chromatography (HPLC) based techniques.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Lisofylline, a novel antiinflammatory agent, protects pancreatic $\beta$-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism
Chen M, et al.
Endocrinology, 143(6), 2341-2348 (2002)
Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes
Yang Z, et al.
Biochemical and Biophysical Research Communications, 344(3), 1017-1022 (2006)
Lisofylline: a potential lead for the treatment of diabetes
Yang Z, et al.
Biochemical Pharmacology, 69(1), 1-5 (2005)
Simultaneous estimation of lisofylline and pentoxifylline in rat plasma by high performance liquid chromatography-photodiode array detector and its application to pharmacokinetics in rat
Italiya KS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1061(1), 49-56 (2017)
Validation of a high
Walczak M, et al.
Acta Poloniae Pharmaceutica, 66(3), 215-224 (2009)

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