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SCC069

Sigma-Aldrich

HSC-T6 Rat Hepatic Stellate Cell Line

Rat

Sinonimo/i:

HSC, Perisinusoidal cells, Ito cells, Hepatic lipocytes, Hepatic pericytes

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About This Item

Codice UNSPSC:
41106514
eCl@ss:
32011203
NACRES:
NA.81

product name

HSC-T6 Rat Hepatic Stellate Cell Line, The HSC-T6 rat hepatic stellate cell line is a valuable cell model for studies of retinoid metabolism based on their similar retinoid phenotype as primary cells.

Origine biologica

rat

Livello qualitativo

100

tecniche

cell based assay: suitable
cell culture | mammalian: suitable

Condizioni di spedizione

ambient

Categorie correlate

Descrizione generale

Hepatocytes and hepatic stellate cells play important roles in retinoid uptake, storage, mobilization and metabolism. Hepatic stellate cells represent only 5-7% of the total cells present in the liver. Isolation of primary stellate cells is thus time-consuming and often accompanied by low yields and considerable lot-to-lot variations. HSC-T6 Rat Hepatic Stellate Cell Line is an immortalized line isolated from SV40 large T-antigen transformed primary stellate cells of male Sprague-Dawley retired breeder rats. HSC-T6 Rat Hepatic Stellate Cell line is a useful model for the study of hepatic retinoid storage and metabolism.

Descrizione della linea cellulare

Hepatocyte Cells

Applicazioni

Research Category
Metabolism

Infectious Diseases

Inflammation & Immunology

Stem Cell Research
Research Sub Category
Liver Physiology
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Componenti

1) ≥1X106 viable HSC-T6 Rat Hepatic Stellate Cells: (Catalog No. SCC069). Store in liquid nitrogen.

Qualità

• Each vial contains ≥ 1X106 viable cells.
• Cells tested negative for infectious diseases by a Mouse/Rat Comprehensive CLEAR panel PCR panel by Charles River Animal Diagnostic Services.
• Cells tested negative for mycoplasma contamination.

Stoccaggio e stabilità

HSC-T6 Rat Hepatic Stellate Cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Ryuichi Noguchi et al.
Molecular medicine reports, 22(4), 2948-2956 (2020-09-19)
An orally bioavailable small molecule inhibitor of plasminogen activator inhibitor‑1 (PAI‑1) is currently being clinically assessed as a novel antithrombotic agent. Although PAI‑1 is known to serve a key role in the pathogenesis of metabolic syndrome (MetS) including nonalcoholic steatohepatitis
Jiunn-Sheng Wu et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 8426051-8426051 (2020-07-28)
Hepatic stellate cell (HSC) activation is a vital driver of liver fibrosis. Recent research efforts have emphasized the clearance of activated HSCs by apoptosis, senescence, or reversion to the quiescent state. LPS induces human HSC activation directly and contributes to
Hongxia Liang et al.
ACS nano, 12(7), 6536-6544 (2018-06-27)
Acute liver failure is a critical condition characterized by global hepatocyte death and often time needs a liver transplantation. Such treatment is largely limited by donor organ shortage. Stem cell therapy offers a promising option to patients with acute liver

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