MABT187

Anti-Kindlin-3 Antibody, clone 181A

clone 181A, from rat

• Sinonimo/i: Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rat
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 181A, monoclonal
• Reattività contro le specie: human
• tecniche: western blot: suitable
• Isotipo: IgG2aκ
• N° accesso NCBI: NP_113659
• N° accesso UniProt: Q86UX7
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... FERMT3(83706)

Descrizione

Descrizione generale

Kindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the β chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted.

Immunogeno

His-tagged recombinant protein corresponding to human Kindlin-3.

Applicazioni

Anti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

Qualità

Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Kindlin-3 in 10 µg of K562 cell lysate.

Descrizione del bersaglio

~76 kDa observed

Stato fisico

Format: Purified

Protein G Purified

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
K562 cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable