MABF158C

Anti-CD152 (CTLA-4) (mouse), PE-Cy7, clone UC10-4F10-11 Antibody

clone UC10-4F10-11, from hamster(Armenian), PE-Cy7

• Sinonimo/i: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), CD152, CD152 (CTLA-4)
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.44

Proprietà

• Origine biologica: hamster (Armenian)
• Livello qualitativo: 100
• Coniugato: PE-Cy7
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: UC10-4F10-11, monoclonal
• Reattività contro le specie: mouse
• Confezionamento: antibody small pack of 25 μg
• tecniche: flow cytometry: suitable
• Isotipo: IgG
• N° accesso UniProt: P09793
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Ctla4(12477)

Descrizione

Descrizione generale

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Applicazioni

This armenian hamster monoclonal Anti-CD152 (CTLA-4) Antibody (mouse), PE-Cy7, clone UC10-4F10-11, Cat. No. MABF1586 is validated for use in Flow Cytometry, for the detection of CD152 (CTLA-4).

Qualità

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.

Altre note

Concentration: Please refer to lot specific datasheet.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable