MAB13426
Anti-MMP-13 Antibody, clone LIPCO IID1
clone LIPCO IID1, Chemicon®, from mouse
Sinonimo/i:
Collagenase-3
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified antibody
Tipo di anticorpo
primary antibodies
Clone
LIPCO IID1, monoclonal
Reattività contro le specie
mouse, rat
Produttore/marchio commerciale
Chemicon®
tecniche
western blot: suitable
Isotipo
IgG1
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... MMP13(4322)
Specificità
It recognizes proteins of ~60 kDa and ~48 kDa which are identified as pro (latent) and activate forms of matrix metalloproteinase-13 (MMP-13; also known as Collagenase-3). Antibody shows no cross-reactivity with the pro and active forms of other MMPs. Human collagenase-3 (MMP13) is a recently identified member of the matrix metalloproteinase (MMP) family that is expressed in breast carcinomas and in articular cartilage from arthritic patients. The MMP-13 gene has been isolated and characterized. This gene is composed of 10 exons and 9 introns and spans over 12.5 kb. The overall organization of the collagenase-3 gene is similar to that of other MMP genes clustered at chromosome 11q22, including fibroblast collagenase (MMP-1), matrilysin (MMP-7), and macrophage metalloelastase (MMP-12), but is more distantly related to genes coding for stromelysin-3 (MMP-11), gelatinase-A (MMP-2), and gelatinase-B (MMP-9), which map outside of this gene cluster.
Cellular Localization:
Cytoplasmic
Cellular Localization:
Cytoplasmic
Immunogeno
Rat MMP-13 from BC-1 cells.
Applicazioni
Anti-MMP-13 Antibody, clone LIPCO IID1 is an antibody against MMP-13 for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
Western Blotting (Lyons, 1991; Lyons, 1993): 1:200-1:400 at room temperature for 2 hours.
Immunofluorescence
Optimal working dilutions must be determined by end user.
Immunofluorescence
Optimal working dilutions must be determined by end user.
Stato fisico
Format: Purified
Stoccaggio e stabilità
Maintain at 2-8°C in undiluted aliquots for up to 12 months.
Risultati analitici
Control
POSITIVE CONTROL: Conditioned, serum-free medium from (PMA-treated) rat fibrosarcoma cells or rat keratinocyte CCL-4.
POSITIVE CONTROL: Conditioned, serum-free medium from (PMA-treated) rat fibrosarcoma cells or rat keratinocyte CCL-4.
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen.
Han, YP; Zhou, L; Wang, J; Xiong, S; Garner, WL; French, SW; Tsukamoto, H
The Journal of Biological Chemistry null
Noninvasive assessment of UV-induced skin damage: comparison of optical measurements to histology and MMP expression.
Papazoglou E, Sunkari C, Neidrauer M, Klement JF, Uitto J
Photochemistry and Photobiology null
Song Ho Chang et al.
Nature communications, 10(1), 1442-1442 (2019-03-31)
Exposure of articular cartilage to excessive mechanical loading is deeply involved in the pathogenesis of osteoarthritis. Here, we identify gremlin-1 as a mechanical loading-inducible factor in chondrocytes, detected at high levels in middle and deep layers of cartilage after cyclic
Protective effects of allopurinol against acute liver damage and cirrhosis induced by carbon tetrachloride: modulation of NF-?B, cytokine production and oxidative stress.
Liseth R Aldaba-Muruato,Mario G Moreno,Mineko Shibayama,Victor Tsutsumi,Pablo Muriel
Biochimica et Biophysica Acta null
SUMO1 regulates endothelial function by modulating the overall signals in favor of angiogenesis and homeostatic responses.
Yang, Ping, et al.
American Journal of Translational Research, 5, 427-440 (2013)
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