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Key Documents

CBL561

Sigma-Aldrich

Anti-CD24 Antibody, clone SN3

clone SN3, Chemicon®, from mouse

Sinonimo/i:

Heat Stable Antigen, HAS

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

SN3, monoclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Chemicon®

tecniche

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

Isotipo

IgG1

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

Specificità

The antibody reacts with the CD24 antigen a heavily glycosylated molecule that migrates as a broad band of 35-45 kDa on both reducing and non-reducing SDS gel electrophoresis. CD24 is attached to the cell membrane via a glycosyl phosphatidylinositol (GPI) anchor and is expressed at multiple stages of B cell development, beginning with the bone marrow CD34 positive pro-B cell compartment and continuing through mature surface IgM positive/IgD positive B cells. CD24 is also expressed on the vast majority of B-lineage acute lymphoblastic leukaemias, B cell chronic lymphocytic leukaemias and B cell non-Hodgkin′s lymphoma. In the normal spleen, mantle zone lymphocytes are CD24 strongly positive, but germinal center cells are CD24 negative or CD24 weakly positive.

Immunogeno

Glycoproteins purified from human NALM-1 cell line.

Applicazioni

Anti-CD24 Antibody, clone SN3 detects level of CD24 & has been published & validated for use in FC, IP, IH.
Immunocytochemistry on frozen tissue sections.

Flow Cytometry: 1:50 - 1:100 per 10e6 cells in 100 μL final volume.

Optimal working dilutions must be determined by the end user.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology

Stato fisico

Affinity purified immunoglobulin by Protein G chromatography. Liquid in 1 mL of PBS, pH 7.4 containing no preservatives.
Format: Purified

Stoccaggio e stabilità

Maintain at -20°C for up to 12 months from date of receipt in undiluted aliquots.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Chronic lymphocytic leukemia progenitor cells carry the antigens T65, BA-1, and Ia.
Perri, R T, et al.
Blood, 61, 871-875 (1983)
Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3.
Barcos, M, et al.
Hematological Oncology, 4, 251-259 null
Clinical usefulness of monoclonal-antibody phenotyping in childhood acute lymphoblastic leukemia.
Kersey, J, et al.
Lancet, 2, 1419-1423 (1982)
New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells.
Fukukawa, T, et al.
Experimental Hematology, 14, 850-855 (1986)
The human fetal omentum: a site of B cell generation.
Solvason, N and Kearney, J F
The Journal of Experimental Medicine, 175, 397-404 (1992)

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