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Key Documents

CBL173

Sigma-Aldrich

Anti-Desmoplakin 1& 2 Antibody, clone DP2.15

clone DP2.15, Chemicon®, from mouse

Sinonimo/i:

Anti-DCWHKTA, Anti-DP

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

DP2.15, monoclonal

Reattività contro le specie

bovine, human, chicken, rat, mouse

Produttore/marchio commerciale

Chemicon®

tecniche

immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable

Isotipo

IgG1

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... DSP(1832)

Specificità

This antibody shows distinct punctate membrane staining of desmoplakins 1 (MW 250 kDa) and 2 (MW 215 kDa) in stratified epithelia and simple epithelia, including glands, urothelium, thymic reticular epithelium, hepatocytes, intercalated disks of myocardium and arachnoid cells of meninges.

Immunogeno

Bovine desmoplakin 1 & 2

Applicazioni

Anti-Desmoplakin 1& 2 Antibody, clone DP2.15 detects level of Desmoplakin 1& 2 & has been published & validated for use in IF, WB & IC.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton
Western blot
Immunohistochemistry: 1:10; Frozen tissue
Immunofluorescence

Optimal working dilutions must be determined by the end user.

Stato fisico

Format: Purified
Lyophilized. Reconstitute in 1 mL distilled water (final solution contains 0.09% sodium
azide, 0.5% BSA in PBS buffer, pH 7.4

Stoccaggio e stabilità

Reconstituted antibody can be stored at 2°-8°C for up to 12 months from date of receipt. Antibody can also be stored at -20°C in undiluted aliquots.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Immunocytochemical identification of epithelium-derived human tumors with antibodies to desmosomal plaque proteins.
Franke, W W, et al.
Proceedings of the National Academy of Sciences of the USA, 80, 543-547 (1983)
Annika Gross et al.
Cellular and molecular gastroenterology and hepatology, 13(4), 1181-1200 (2021-12-21)
Desmosomes are intercellular junctions connecting keratin intermediate filaments of neighboring cells. The cadherins desmoglein 2 (Dsg2) and desmocollin 2 mediate cell-cell adhesion, whereas desmoplakin (Dsp) provides the attachment of desmosomes to keratins. Although the importance of the desmosome-keratin network is
Wenxiu Ning et al.
Cell stem cell, 28(3), 436-452 (2020-12-03)
Basal stem cells fuel development, homeostasis, and regeneration of the epidermis. The proliferation and fate decisions of these cells are highly regulated by their microenvironment, including the basement membrane and underlying mesenchymal cells. Basal progenitors give rise to differentiated progeny

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