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Key Documents

AB144

Sigma-Aldrich

Anti-Choline Acetyltransferase Antibody

CHEMICON®, goat polyclonal

Sinonimo/i:

ChAT

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

product name

Anti-Choline Acetyltransferase Antibody, serum, Chemicon®

Origine biologica

goat

Livello qualitativo

Forma dell’anticorpo

serum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

guinea pig, mouse, rat

Produttore/marchio commerciale

Chemicon®

tecniche

immunohistochemistry: suitable
western blot: suitable

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Chat(12647)
rat ... Chat(290567)

Descrizione generale

Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-cholinacetyltransferase a useful specific marker.

Specificità

Recognizes cholinergic neurons in brain and central nervous systems.

Immunogeno

Human placental enzyme.

Applicazioni

Anti-Choline Acetyltransferase Antibody is an antibody against Choline Acetyltransferase for use in IH & WB.
Immunoblot: 1:1,000-1:5,000

Immunohistochemistry: 1:500-1:1,000. See page two of this data sheet.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neuronal & Glial Markers

Descrizione del bersaglio

70 kDa

Stato fisico

Goat antisera, liquid, no preservatives.
Unpurified

Stoccaggio e stabilità

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
Rat brain tissue

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system.
Stanley, EM; Fadel, J
Synapse null
M A Raghanti et al.
Neuroscience, 184, 1-15 (2011-04-21)
Long projection axons from the Ch4 cell group of the nucleus basalis of Meynert (nbM) provide cholinergic innervation to the neurons of the cerebral cortex. This cortical cholinergic innervation has been implicated in behavioral and cognitive functions, including learning and
In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis.
Fengfeng Tian,Nobutoshi Morimoto,WenTao Liu,Yasuyuki Ohta,Kentaro Deguchi,Kazunori Miyazaki,Koji Abe
Autophagy null
Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP(8)).
Yonghong Zhu,Cleo C L Lee,W P Lam,Maria S M Wai,John A Rudd,David T Yew
Biogerontology null
Janneke C Zant et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(6), 2057-2067 (2016-02-13)
Understanding the control of sleep-wake states by the basal forebrain (BF) poses a challenge due to the intermingled presence of cholinergic, GABAergic, and glutamatergic neurons. All three BF neuronal subtypes project to the cortex and are implicated in cortical arousal

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