ABT174
Anti-LGN Antibody
serum, from rabbit
Sinonimo/i:
G-protein-signaling modulator 2, Mosaic protein LGN, LGN
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
application:
WB
Reattività contro le specie:
mouse, rat
tecniche:
western blot: suitable
citations:
8
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
serum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
mouse, rat
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
mouse ... Gpsm2(76123)
Descrizione generale
LGN is also known as G-protein-signaling modulator 2 (GPSM2). LGN has an important role in cellular structure and spindle pole orientation. LGN also stabilizes the apical complex during neuroblast divisions. LGN defects lead to Chudley-McCullough syndrome as well as a multiple micronuclei phenotype due to chromosomal mis-segregation and cell division errors.
Specificità
Other Homologies: Human (85% sequence homology), Chicken (75% sequence homology).
Immunogeno
GST-tagged recombinant protein corresponding to mouse LGN.
Applicazioni
Anti-LGN Antibody is a highly specific rabbit polyclonal antibody, that targets LGN & has been tested in western blotting.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected LGN in mouse E16 brain tissue lysate.
Qualità
Evaluated by Western Blotting in rat E16 heart tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected LGN in rat E16 heart tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected LGN in rat E16 heart tissue lysate.
Descrizione del bersaglio
~77 kDa observed. Uncharacterized bands may be observed at ~30 kDa, ~60 kDa, and ~70 kDa in some cell lysates.
Stato fisico
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified
Stoccaggio e stabilità
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Risultati analitici
Control
Heart tissue lysate
Heart tissue lysate
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Par3-mInsc and G?i3 cooperate to promote oriented epidermal cell divisions through LGN.
Williams, SE; Ratliff, LA; Postiglione, MP; Knoblich, JA; Fuchs, E
Nature Cell Biology null
Kendall J Lough et al.
eLife, 8 (2019-12-14)
During organogenesis, precise control of spindle orientation balances proliferation and differentiation. In the developing murine epidermis, planar and perpendicular divisions yield symmetric and asymmetric fate outcomes, respectively. Classically, division axis specification involves centrosome migration and spindle rotation, events occurring early
Christie K Campla et al.
eNeuro, 9(5) (2022-10-01)
Trafficking of transducin (Gαt) in rod photoreceptors is critical for adaptive and modulatory responses of the retina to varying light intensities. In addition to fine-tuning phototransduction gain in rod outer segments (OSs), light-induced translocation of Gαt to the rod synapse
Martina Bonucci et al.
Nature communications, 11(1), 3200-3200 (2020-06-26)
mTOR activation is essential and sufficient to cause polycystic kidneys in Tuberous Sclerosis Complex (TSC) and other genetic disorders. In disease models, a sharp increase of proliferation and cyst formation correlates with a dramatic loss of oriented cell division (OCD).
Maria Fankhaenel et al.
Nature communications, 14(1), 151-151 (2023-01-12)
Oriented cell divisions are critical for the formation and maintenance of structured epithelia. Proper mitotic spindle orientation relies on polarised anchoring of force generators to the cell cortex by the evolutionarily conserved protein complex formed by the Gαi subunit of
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