ABS549
Anti-MuSK Antibody
serum, from rabbit
Sinonimo/i:
Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
serum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
mouse, human
tecniche
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... MUSK(4593)
Descrizione generale
MuSK, also known as Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, or Muscle-specific kinase receptor, and encoded by the gene MUSK, a key muscle specific receptor tyrosine kinase that plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). The NMJ is the special synapse between the motor neuron and the skeletal muscle. MuSK activation in the myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in the subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors in the postsynaptic membrane. MuSK also plays a role in the CNS by mediating cholinergic responses, synaptic plasticity and memory function. MuSK is a membrane bound protein localized to the postsynaptic side of the cell membrane at the neuromuscular junction in muscle cells.
Immunogeno
Epitope: Extracellular domain
Recombinant protein corresponding to the extracellular domain of mouse MuSK.
Applicazioni
Anti-MuSK antibody is an antibody against MuSK for use in western blotting, IHC & IP.
Research Category
Signaling
Signaling
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
Western Blotting Analysis: A representative lot detected MuSK in C2C12 cell lysate (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunohistochemistry Analysis: A representative lot detected MuSK in mouse soleus muscle tissue (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunoprecipitation Analysis: A representative lot immunoprecipitated MuSK in C2C12 cell lysate (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunohistochemistry Analysis: A representative lot detected MuSK in mouse soleus muscle tissue (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunoprecipitation Analysis: A representative lot immunoprecipitated MuSK in C2C12 cell lysate (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Qualità
Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected MuSK in 10 µg of HEK293 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected MuSK in 10 µg of HEK293 cell lysate.
Descrizione del bersaglio
~110 kDa observed. Uncharacterized band(s) may appear in some lysates.
Stato fisico
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified
Stoccaggio e stabilità
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Luca Simeone et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(19), 6620-6634 (2010-05-14)
Erbin, a binding partner of ErbB2, was identified as the first member of the LAP family of proteins. Erbin was shown at postsynaptic membranes of the neuromuscular junction (NMJ) or in cultured C2C12 myotubes (1) to be concentrated, (2) to
Patrick Scotton et al.
The Journal of biological chemistry, 281(48), 36835-36845 (2006-10-03)
Agrin induces the aggregation of postsynaptic proteins at the neuromuscular junction (NMJ). This activity requires the receptor-tyrosine kinase MuSK. Agrin isoforms differ in short amino acid stretches at two sites, called A and B, that are localized in the two
Tatiana Cheusova et al.
Journal of neurochemistry, 99(2), 450-457 (2006-08-11)
One of the master regulators of postsynaptic neuromuscular synaptogenesis is the muscle-specific receptor tyrosine kinase (MuSK). In mammals prominent MuSK expression is believed to be restricted to skeletal muscle. Upon activation by nerve-derived agrin MuSK-dependent signalling participates in both the
Asma Ben Ammar et al.
PloS one, 8(1), e53826-e53826 (2013-01-18)
Congenital myasthenic syndromes (CMSs) are a heterogeneous group of genetic disorders affecting neuromuscular transmission. The agrin/muscle-specific kinase (MuSK) pathway is critical for proper development and maintenance of the neuromuscular junction (NMJ). We report here an Iranian patient in whom CMS
Tatiana Cheusova et al.
Genes & development, 20(13), 1800-1816 (2006-07-05)
The release of Agrin by motoneurons activates the muscle-specific receptor tyrosine kinase (MuSK) as the main organizer of subsynaptic specializations at the neuromuscular junction. MuSK downstream signaling is largely undefined. Here we show that protein kinase CK2 interacts and colocalizes
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